Evidence supporting the use of: Trehalose
For the health condition: Dementia

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Trehalose is a naturally occurring disaccharide sugar that has gained attention in recent years for its potential neuroprotective properties, particularly in the context of neurodegenerative diseases such as dementia and Alzheimer's disease. The scientific interest in trehalose stems from preclinical studies demonstrating its ability to induce autophagy, a cellular process that removes damaged proteins and organelles, potentially reducing the accumulation of toxic aggregates commonly seen in dementia-related conditions. Several animal studies have shown that trehalose administration can decrease amyloid-beta and tau pathology, improve synaptic function, and enhance cognitive performance in mouse models of Alzheimer's disease. Additionally, trehalose has been shown to exert antioxidant and anti-inflammatory effects, which may contribute to its neuroprotective profile. However, despite these promising preclinical findings, robust clinical evidence in humans is currently lacking. Only a few small-scale human studies have been conducted, and these are primarily focused on safety and pharmacokinetics rather than clinical efficacy for dementia. No large, randomized controlled trials have conclusively demonstrated that trehalose supplementation improves cognitive function or slows disease progression in patients with dementia. As such, while there is scientific rationale and preclinical support for trehalose in this context, its use for treating or supporting dementia in humans remains experimental and not yet validated by strong clinical evidence.

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