Evidence supporting the use of: Vitamin D (unspecified)
For the health condition: Dementia

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin D has been investigated for its potential role in supporting cognitive function and slowing the progression of dementia, including Alzheimer’s disease. There is scientific interest largely because low levels of vitamin D are correlated with increased risk of cognitive decline and dementia in observational studies. Several mechanisms have been proposed, including vitamin D’s role in neuroprotection, reduction of inflammation, and support of neurotransmitter synthesis. However, current evidence from randomized controlled trials (RCTs) is limited and inconclusive. Some small studies suggest that correcting vitamin D deficiency may improve or stabilize cognitive function in elderly populations, but meta-analyses and systematic reviews (e.g., by The Cochrane Library and other reputable sources) generally conclude that the quality of evidence is low and that supplementation does not consistently produce significant clinical benefits in dementia patients. Guidelines from major health organizations do not currently recommend vitamin D supplementation solely for the prevention or treatment of dementia, though they may recommend it for bone health in older adults. In summary, while there is a scientific rationale and some supporting evidence linking vitamin D status and cognitive health, robust proof of efficacy as a treatment for dementia is lacking, and more high-quality trials are needed.

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