Evidence supporting the use of: Vitamin E (vitamin E acetate)
For the health condition: Dementia

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin E, particularly in the form of vitamin E acetate, has been investigated for its potential role in supporting or treating dementia, including Alzheimer's disease. The rationale comes from vitamin E’s antioxidant properties, as oxidative stress is thought to contribute to neurodegeneration. Several clinical trials have examined vitamin E supplementation in patients with dementia. The most notable is the 1997 study published in the New England Journal of Medicine, which found that high-dose vitamin E (2000 IU per day) slightly delayed progression of Alzheimer’s disease compared to placebo in patients with moderate disease. However, the benefit was modest, and later studies have produced mixed results, with some showing no significant cognitive improvement or disease modification. Meta-analyses generally conclude that while vitamin E may offer a small delay in functional decline, it does not meaningfully improve cognitive outcomes or prevent dementia in healthy individuals. Moreover, high doses of vitamin E have been associated with increased risk of hemorrhagic stroke and all-cause mortality in some populations. In summary, there is scientific investigation supporting the use of vitamin E for dementia, but the quality and consistency of evidence are limited, and clinical benefit appears minimal. Current guidelines do not recommend routine vitamin E supplementation for dementia prevention or treatment.

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