Evidence supporting the use of: Apigenin
For the health condition: Depression

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Apigenin is a naturally occurring flavonoid found in various plants, including chamomile, parsley, and celery. Its use for depression is primarily supported by preclinical scientific research rather than longstanding traditional use. Animal studies have demonstrated that apigenin exhibits antidepressant-like effects, possibly through its ability to modulate neurotransmitter systems, including serotonergic, dopaminergic, and GABAergic pathways. For example, research in rodent models has shown that apigenin administration can lead to reduced immobility time in forced swim and tail suspension tests—behavioral assays commonly used to assess antidepressant activity. Additionally, apigenin's anti-inflammatory and antioxidant properties may contribute to its potential benefits, as inflammation and oxidative stress have been implicated in the pathophysiology of depression.

However, robust clinical evidence in humans is lacking. Only limited human studies exist, and these are often preliminary or focus on related outcomes such as anxiety or sleep quality rather than direct measures of depression. Thus, while the scientific rationale is promising and preclinical evidence is supportive, there is not yet strong clinical validation to recommend apigenin as a treatment for depression. Further well-designed human trials are needed to establish its efficacy and safety for this condition.

More about Apigenin
More about Depression

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amino acids
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anthocyanins
ashwagandha
waterhyssop
basil
bergamot
beta caryophyllene
bifidobacterium longum
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chamomile
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clove
coenzyme Q10 (CoQ10)
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damiana
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eleuthero
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fish oil
fish protein
flavonols
folate
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ginger
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green tea
hemp oil
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moringa
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n-acetyl-cysteine (NAC)
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omega-3 fatty acids
phenolic compounds
phosphatidylserine
phospholipids
phytocannabinoids
polygala root
pomegranate
prebiotic blend (proprietary)
pregnenolone
protein
butyric acid
quercetin
reishi mushroom
resveratrol
rhodiola
rose oil
rosemary
saffron
sage
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sceletium
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isoliquiritigenin
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Products containing Apigenin

We currently have no products on Vitabase that contain this ingredient.