Evidence supporting the use of: Bacopa glycoside (unspecified)
For the health condition: Depression

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Bacopa glycosides, particularly those found in Bacopa monnieri extracts (commonly referred to as bacosides), have been investigated for their potential neuroprotective and adaptogenic effects. There is a traditional background for the use of Bacopa in Ayurvedic medicine for cognitive enhancement and stress relief, but its specific use for depression is more recent and based on emerging scientific research. Preclinical animal studies have demonstrated that Bacopa extracts can modulate neurotransmitter levels (such as serotonin and dopamine), reduce oxidative stress, and influence neuroinflammation—mechanisms relevant to the pathophysiology of depression. Some small-scale human clinical trials have assessed Bacopa’s impact on mood, reporting modest improvements in measures of anxiety and mood, though depression-specific endpoints are less frequently studied.

However, the evidence remains preliminary and somewhat inconsistent. Most human studies have small sample sizes, use mixed populations (not specifically individuals with diagnosed depression), and often employ whole-plant extracts rather than isolated glycosides. Systematic reviews and meta-analyses note potential but call for larger, better-controlled trials specifically targeting depressive symptoms. Currently, Bacopa glycosides are not considered a first-line or well-established treatment for depression, but ongoing research continues to evaluate their role as adjunctive agents.

More about Bacopa glycoside (unspecified)
More about Depression

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Products containing Bacopa glycoside (unspecified)

We currently have no products on Vitabase that contain this ingredient.