Evidence supporting the use of: Baicalin
For the health condition: Depression

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Baicalin is a flavonoid compound extracted from the roots of Scutellaria baicalensis (Chinese skullcap), a traditional Chinese medicinal herb. While baicalin has a long history of use in traditional medicine, its application for depression is primarily supported by emerging scientific evidence rather than tradition.

Preclinical studies have demonstrated that baicalin exhibits antidepressant-like effects in animal models of depression. These effects appear to be mediated by several mechanisms, including modulation of the hypothalamic-pituitary-adrenal (HPA) axis, enhancement of neurogenesis, anti-inflammatory actions, regulation of neurotransmitters such as serotonin and dopamine, and attenuation of oxidative stress. For example, studies in rodents have shown that baicalin administration can reduce depressive-like behaviors in tests such as the forced swim test and tail suspension test, and may normalize stress-induced changes in brain chemistry.

However, high-quality human clinical trials are lacking. Most evidence to date is limited to laboratory and animal research, with only a few small-scale or preliminary human studies related to mood or anxiety. Therefore, while there is a scientific rationale and promising preclinical data, the clinical evidence supporting baicalin’s use for depression in humans is still insufficient, and its rating is moderate to low (2/5). Further robust, placebo-controlled human studies are necessary before baicalin can be confidently recommended for depression.

More about baicalin
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Products containing baicalin

We currently have no products on Vitabase that contain this ingredient.