Synopsis

Source of validity: Traditional
Rating (out of 5): 1

Dodder (Cuscuta spp.) has a long history of use in traditional herbal medicine, particularly within Traditional Chinese Medicine (TCM). In TCM, dodder seed (often referred to as "Tu Si Zi") is valued for its purported ability to tonify the kidney and liver, and is sometimes included in formulas aimed at improving mood, energy, and overall vitality. While dodder is not specifically highlighted as a primary treatment for depression in classic texts, its use in formulas for “shen” (spirit) disturbances or general weakness may have led to its occasional traditional application for mood disorders, including depression.

However, scientific evidence supporting the efficacy of dodder for depression is limited. There are a few preliminary animal studies suggesting that extracts from dodder seeds may possess neuroprotective or anti-inflammatory properties, which could theoretically influence mood. For example, some research has noted the antioxidant and neuroprotective effects of certain compounds found in dodder, but direct studies on depression models are sparse and not conclusive. No high-quality human clinical trials have established its effectiveness for treating depression.

In summary, while dodder is traditionally used for vitality and sometimes for mood-related symptoms, there is minimal scientific validation for its use specifically in treating depression. Any claims of efficacy are primarily rooted in traditional practice rather than robust modern evidence.

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