Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Epigallocatechin gallate (EGCG), a major catechin in green tea, has garnered scientific interest for its potential role in supporting or treating depression, though its use is not deeply rooted in traditional medicine specifically for mood disorders. Preclinical studies suggest that EGCG may exert antidepressant-like effects primarily through its antioxidant, anti-inflammatory, and neuroprotective properties. In animal models, EGCG has been shown to modulate neurotransmitter levels (such as serotonin, dopamine, and norepinephrine), inhibit monoamine oxidase activity, and upregulate brain-derived neurotrophic factor (BDNF), all mechanisms implicated in depression pathophysiology. Some small human studies and epidemiological research have hinted at an association between green tea consumption and lower prevalence of depressive symptoms, but these studies are generally observational and not specific to EGCG. Clinical trials directly investigating EGCG supplementation in individuals with depression are very limited and have produced inconclusive results. Consequently, while mechanistic and animal data are promising, strong clinical evidence is lacking. In summary, EGCG’s use for depression is supported by a scientific rationale and preclinical evidence, but the current level of clinical validation is low (evidence rating: 2/5). More rigorous human trials are needed to establish its efficacy and safety as a treatment for depression.

More about epigallocatechin gallate (EGCG)
More about Depression

Other ingredients used for Depression

Other health conditions supported by epigallocatechin gallate (EGCG)

Products containing epigallocatechin gallate (EGCG)

Metagenics Akkermansia Co.™ Healthy Weight with Glucose Control
Designs For Health EGCg
Metagenics Wellness Essentials Healthy Balance Daily Packs