Evidence supporting the use of: Ginseng, Panax
For the health condition: Depression

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Panax ginseng has been investigated for its potential effects on depression, with some scientific studies providing preliminary support for its use, though the overall quality of evidence remains low to moderate. Ginseng contains ginsenosides, which are believed to influence neurotransmitter systems such as dopamine, serotonin, and norepinephrine, all implicated in mood regulation. Several animal studies have demonstrated that Panax ginseng extracts can produce antidepressant-like effects, possibly through anti-inflammatory actions and modulation of the hypothalamic-pituitary-adrenal (HPA) axis.

Clinical evidence in humans is limited but growing. A few randomized controlled trials (RCTs) have explored ginseng’s effect on depressive symptoms, often as part of studies on fatigue or quality of life in patients with chronic illnesses. Some of these studies have reported mild improvements in mood and depression scores, but sample sizes are generally small, and methodological limitations (such as short duration or lack of blinding) are common. Systematic reviews conclude that while there is some evidence for antidepressant effects of Panax ginseng, it is not robust enough to support clinical recommendations. Larger, well-controlled trials are needed to establish efficacy and safety.

In summary, Panax ginseng is supported by scientific rationale and some preliminary evidence for use in depression, but current data are insufficient for strong clinical endorsement.

More about Ginseng, Panax
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Products containing Ginseng, Panax

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