Evidence supporting the use of: Ginsenosides
For the health condition: Depression

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Ginsenosides, the primary active components of ginseng, have been investigated for their potential antidepressant effects in both preclinical and limited clinical studies. The use of ginseng for mood and vitality has a long tradition in East Asian medicine, but scientific interest has focused on ginsenosides' specific mechanisms of action in the brain. Animal studies have shown that ginsenosides, particularly Rg1 and Rb1, can modulate neurotransmitter levels (such as serotonin, dopamine, and noradrenaline) and exert neuroprotective and anti-inflammatory effects. These mechanisms are relevant to the pathophysiology of depression. Some in vitro and animal models indicate that ginsenosides may reduce depressive-like behaviors and improve neuroplasticity through pathways involving BDNF (brain-derived neurotrophic factor) and the HPA (hypothalamic-pituitary-adrenal) axis.

However, evidence from human clinical trials is limited and often of low quality, with small sample sizes and inconsistent results. Meta-analyses and systematic reviews highlight a potential for benefit but also underscore the need for more rigorous, larger-scale randomized controlled trials to confirm efficacy and safety. In summary, while there is a plausible scientific rationale and encouraging preclinical data, the clinical evidence for using ginsenosides to support or treat depression remains preliminary. Therefore, the current level of scientific support can be rated as low to moderate.

More about Ginsenosides
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Products containing Ginsenosides

We currently have no products on Vitabase that contain this ingredient.