Relationship: Depression and inositol

Evidence supporting the use of: Inositol
For the health condition: Depression

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Synopsis
Other ingredients for this health condition
Other health conditions supported by this ingredient
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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Inositol, a naturally occurring carbocyclic sugar, has been investigated for its potential role in supporting or treating depression. Scientific interest in inositol’s use for depression stems from its involvement in cellular signaling pathways, particularly those related to neurotransmitters such as serotonin. Several clinical studies, including randomized controlled trials, have assessed the efficacy of inositol supplementation in individuals with depression. Some small-scale studies have shown modest improvements in depressive symptoms compared to placebo. For example, a double-blind study published in the American Journal of Psychiatry (1995) found that 12 grams of inositol daily improved depression symptoms in some patients. However, subsequent larger and more rigorous studies have produced mixed or negative results, with some failing to replicate the initial positive findings.

A 2014 systematic review in the Cochrane Database concluded that the evidence for inositol in treating depression is weak and insufficient for clinical recommendations. Major guidelines do not include inositol as a standard treatment for depression. In summary, while there is some scientific rationale and early evidence suggesting possible benefit, the overall strength and consistency of the data are limited. Its use is not widely endorsed by the medical community, and more robust, larger-scale trials are needed to confirm any antidepressant effects of inositol.

More about inositol
More about Depression

Other ingredients used for Depression

5-Hydroxytryptophan (5-HTP)
5-methyltetrahydrofolate glucosamine
7,8-Dihydroxyflavone
Acetyl L-carnitine
Acetyl-L-Tyrosine
Agarwood
Agmatine
Albizia
algal oil
Algal protein
Almond fruit
Alpha lactalbumin
alpha-linolenic acid (ALA)
alpinia galangal
amino acids
Amor seco
anchovies
Angelica
aniracetam
anthocyanins
apigenin
Ardisia
arginine creatine
ashwagandha
Asteraceae
Bacopa
Bacopin
bacoside
baicalin
Baikal Skullcap
basil
bee products
Beef liver
bergamot
beta caryophyllene
beta-hydroxybutyrate
betony
Bifidobacterium longum
biogenic amine
biopterin
Black Hellebore
black tea
blackboard tree
brahmi
Broussonetia
Butea monosperma
butyric acid
bасора
Caesalpinia crista
caffeine
Camellia sinensis
cannabichromene
cannabidiol
Cannabis sativa oil
Canscora
caryophyllene
catalpol
Centella asiatica
chamomile
Chinese raisintree
Chinese salvia root
chocolate
choline
cistanche
citicoline
Citrus
Clary sage
clove
cocoa
coconut
Codonopsis
coenzyme Q10 (CoQ10)
cola nut
commiphora
Convolvulus pluricaulis
Convolvulus prostratus
cordyceps
cowslip
creatine
creatine monohydrate
crocin
Curcuma
curcumen
curcumin
Curcuminoid
Cymbopogon martini
D-phenylalanine
damiana
devil\'s club
DHA (docosahexaenoic acid)
DHEA
DHEA (dehydroepiandrosterone)
docosahexaenoic Acid
dodder
dopamine
DPA (docosapentaenoic acid)
egg
eicosapentaenoic acid
Eicosatetraenoic acid
eleuthero
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
estrogen
fatty acids
fish
fish oil
fish protein
flavonoids
flavonols
folate
folic acid
folinic acid
fragrant rosewood
frankincense
fungus
gardenia
gastrodia
gastrodin
ginger
ginkgo biloba
ginseng
Ginsenosides
Glutamate
Glycine
gotu kola
Greek mountain tea
green tea
Griffonia simplicifolia
guanidinoacetic acid
Gypenoside
Helicteres isora
Hellebore
hemp
hemp oil
hericium mushroom
Honokiol
hyperforin
Hypericin
Hypericum
icariin
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inositol
inositol phosphate
isoliquiritigenin
jasmine
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jujube
kanna
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krill oil
l-5-methyltetrahydrofolate glucosamine salt (5-MTHF)
L-carnosine
L-glycine
L-methionine
L-phenylalanine
L-theanine
L-tryptophan
l-tyrosine
lactalbumin
lactium casein decapeptide
lactoglobulin
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Lavandin
lavender
Lebbek
lemon balm
lemongrass
ligustilides
limonene
linalool
lingzhi
lion's mane
lipids
liquid liver fractions
lithium orotate
little ironweed
long pepper
luteolin
Lycopodium
maca
magnesium
magnolia
magnolol
Marine fat
Marine lipid
Marine protein
Matcha
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Melatonin
Mesembrine
Methylcobalamin
Methylxanthine
Milk Protein
Mimosa
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Morinda
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Mulungu
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Nardostachys
Nigella seed
Nutmeg
Nymphaea caerulea
Nymphaea nouchali
omega-3 fatty acids
Onosma bracteatum
Oroxylum indicum
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Oxindole alkaloids
paeoniflorin
Palmitoylethanolamide (PEA)
Patchouli oil
Pentacyclic triterpenoids
peony
Petiveria
phenolic compounds
Phenylethylamine (PEA)
phosphatidylserine
Phosphocreatine
phospholipids
Physalis angulata
phytocannabinoids
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Piper nigrum
poly-thyronine
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polygala root
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polyunsaturated fat
pomegranate
prebiotic blend (proprietary)
pregnenolone
protein
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pyrroloquinoline quinone
quercetin
reishi mushroom
resveratrol
Rhodiola
Rosabin
rosavins
rose
rose oil
rosemary
rosmarinic acid
royal jelly
Rubiaceae
rue
Safed musli
saffron
Safranal
sage
Salidroside
Salmon Oil
Salvia
SAMe (S-adenosyl-L-methionine disulfate p-toluensulfate)
Sandalwood
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sceletium
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Scleranthus annus
selenium
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specialized pro-resolving mediators (SPMs)
Sphaeranthus indicus
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spirulina
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star of Bethlehem
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suma
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Tea
Terpenoids
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thyroid substance
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trace minerals
Trichilia catigua
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turmeric
Uncaria
Uridine
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velvet bean
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vitamin B
vitamin B12
vitamin B6
vitamin C
vitamin D
vitamin D3
Walnut
Waterhyssop
Whey protein
Withanolides
Wogonin
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Ylang ylang
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Yuzu
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Other health conditions supported by inositol

Anxiety
Anxiety Disorders
Bipolar Mood Disorder
Bulimia
Depression
Diabetes
Memory and Brain Function
Obsessive Compulsive Disorder
PMS (general)

Products containing inositol

Health Concerns

Brands

Evidence supporting the use of: Inositol
For the health condition: Depression

Table of Contents

Synopsis

Other ingredients used for Depression

Other health conditions supported by inositol

Products containing inositol

Health Concerns

Brands

Evidence supporting the use of: InositolFor the health condition: Depression

Table of Contents

Synopsis

Other ingredients used for Depression

Other health conditions supported by inositol

Products containing inositol

Evidence supporting the use of: Inositol
For the health condition: Depression