Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Inositol and its phosphate derivatives, such as inositol hexaphosphate (phytate), have been investigated for their potential role in supporting mental health, including depression. The primary scientific focus has been on myo-inositol, a naturally occurring isomer, which acts as a precursor for several important signaling molecules in the brain. Several small clinical trials and open-label studies have explored the efficacy of inositol supplementation in mood disorders, including depression. Some early studies (e.g., Levine et al., 1995, Am J Psychiatry) demonstrated modest benefits in depressive symptoms when using high doses of inositol (up to 12g/day). Proposed mechanisms include modulation of neurotransmitter systems, particularly serotonin, via inositol’s role in the phosphatidylinositol signaling pathway.

Despite these findings, the overall quality of evidence is low. Many studies are small, not always well-controlled, and sometimes show conflicting results. Meta-analyses and systematic reviews generally conclude that while inositol may have some potential, the evidence is insufficient to recommend it as a primary treatment for depression. There is no strong historical tradition of using inositol phosphate specifically for depression, and most clinical studies focus on myo-inositol rather than its phosphate forms. In summary, while there is preliminary scientific interest, the evidence base is weak and not definitive.

More about Inositol phosphate
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Other health conditions supported by Inositol phosphate

Depression
Diabetes
Obsessive Compulsive Disorder

Products containing Inositol phosphate

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