Synopsis

Source of validity: Scientific
Rating (out of 5): 2

L-glycine, a non-essential amino acid, has some scientific rationale for its use in supporting or treating depression, though the evidence is limited and preliminary. Glycine acts as an inhibitory neurotransmitter in the central nervous system and also serves as a co-agonist at the NMDA (N-methyl-D-aspartate) glutamate receptor. Dysregulation of glutamatergic neurotransmission has been implicated in the pathophysiology of depression, and some antidepressant effects have been linked to modulation of the NMDA receptor system (e.g., ketamine). Several small studies and animal models have suggested that glycine supplementation may exert anxiolytic and antidepressant-like effects, likely through its action on neurotransmitter systems involved in mood regulation. For example, a few clinical trials have explored high-dose glycine as an adjunct in schizophrenia and other psychiatric conditions, noting some mood improvements. However, evidence for its direct efficacy in major depressive disorder (MDD) is sparse; most human research is limited by small sample sizes, lack of replication, and methodological weaknesses. Overall, while there is a scientific basis for the hypothesis that L-glycine could influence depression through its effects on neurochemistry, robust clinical evidence is lacking. Current support for its use in depression is mostly theoretical or based on early-stage research. More high-quality clinical trials are needed to clarify its effectiveness and safety in this context.

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Other ingredients used for Depression

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Products containing L-glycine

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