Relationship: Depression and magnesium

Evidence supporting the use of: Magnesium
For the health condition: Depression

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Magnesium has garnered scientific interest as a potential adjunctive therapy for depression. Several studies have observed that individuals with depression often have lower serum magnesium levels, and magnesium is involved in numerous biochemical pathways in the brain, including those related to neurotransmitter function and the regulation of the stress response system. Randomized controlled trials (RCTs) have provided some support: for example, a 2017 open-label RCT published in PLoS ONE found that magnesium supplementation (248 mg/day of elemental magnesium) led to significant improvements in depression and anxiety symptoms compared to placebo over a 6-week period. Other smaller studies and meta-analyses suggest a potential benefit, particularly for individuals with low magnesium status or mild-to-moderate depression.

However, the quality and size of the evidence base is still limited. Most trials have small sample sizes, short durations, and variable dosages and formulations, and blinding is sometimes inadequate. Current clinical guidelines do not include magnesium as a first-line treatment for depression, but they do acknowledge its potential in cases where deficiency is suspected. In summary, there is scientific evidence suggesting magnesium may help support the treatment of depression, but more large-scale, well-controlled studies are needed to establish its efficacy and determine which patient populations are most likely to benefit.

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Other ingredients used for Depression

5-Hydroxytryptophan (5-HTP)
Acetyl L-carnitine
algal oil
alpha-linolenic acid (ALA)
amino acids
anchovies
anthocyanins
ashwagandha
Waterhyssop
basil
bergamot
beta caryophyllene
Bifidobacterium longum
black tea
Indian frankincense
bасора
caffeine
Cannabis sativa oil
chamomile
Chinese salvia root
choline
citicoline
clove
coenzyme Q10 (CoQ10)
cordyceps
creatine monohydrate
turmeric
curcumin
damiana
DHA (docosahexaenoic acid)
DHEA (dehydroepiandrosterone)
DPA (docosapentaenoic acid)
eleuthero
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fish oil
fish protein
flavonols
folate
gardenia
ginger
ginkgo biloba
ginseng
gotu kola
Greek mountain tea
green tea
hemp oil
Indian tinospora
inositol
jujube
krill oil
l-5-methyltetrahydrofolate glucosamine salt (5-MTHF)
L-carnosine
L-glycine
L-methionine
L-phenylalanine
L-theanine
L-tryptophan
l-tyrosine
lactium casein decapeptide
lavender
lion's mane
lithium orotate
liquid liver fractions
luteolin
maca
magnesium
magnolia
Marine lipid
Matcha
Melatonin
Moringa
Muira puama
N-acetyl-cysteine (NAC)
Acetyl-L-Tyrosine
omega-3 fatty acids
phenolic compounds
phosphatidylserine
phospholipids
phytocannabinoids
polygala root
pomegranate
prebiotic blend (proprietary)
pregnenolone
protein
butyric acid
quercetin
reishi mushroom
resveratrol
Rhodiola
rose oil
rosemary
saffron
sage
SAMe (S-adenosyl-L-methionine disulfate p-toluensulfate)
sceletium
selenium
specialized pro-resolving mediators (SPMs)
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spirulina
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velvet bean
vitamin B
vitamin B12
vitamin B6
vitamin C
vitamin D
vitamin D3
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suma
gastrodia
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alpinia galangal
commiphora
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dodder
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royal jelly
polyphenols
trace minerals
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cocoa
thyroid substance
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arginine creatine
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aniracetam
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beta-hydroxybutyrate
biopterin
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bee products
bacoside
baicalin
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biogenic amine
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caryophyllene
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crocin
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catalpol
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Chinese raisintree
curcumen
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Centella asiatica
chocolate
creatine
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cowslip
cannabidiol
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cola nut
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cannabichromene
docosahexaenoic Acid
D-phenylalanine
DHEA
devil\'s club
dopamine
egg
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eicosapentaenoic acid
estrogen
folinic acid
folic acid
flavonoids
fragrant rosewood
fish
fatty acids
fungus
frankincense
guanidinoacetic acid
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Griffonia simplicifolia
Gypenoside
Glutamate
Glycine
gastrodin
Honokiol
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hyperforin
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hericium mushroom
hemp
isoliquiritigenin
long pepper
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jasmine
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ligustilides
limonene
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little ironweed
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lactoglobulin
linalool
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magnolol
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pyrroloquinoline quinone
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polyunsaturated fat
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Other health conditions supported by magnesium

Abdominal Pain
Abscesses
Acid Indigestion
Addictions (drugs)
Addictions (general remedies for)
Adrenal Fatigue
Aging (prevention)
Alcoholism
Alkalosis
Allergies (respiratory)
Alzheimer's Disease
Angina
Anorexia
Anxiety
Anxiety Disorders
Apathy
Arrhythmia
Arteriosclerosis
Arthritis
Asthma
Athletic and Exercise Aids
Attention Deficit Disorder
Autism
Autoimmune Disorders
Backache
Bipolar Mood Disorder
Birth Control (countering side effects)
Body Building
Body Odor
Boils
Broken Bones
Bronchitis
Bulimia
Calcium Deficiency
Calcium Deposits
Cancer Treatment (reducing side effects)
Canker Sores
Carbuncles
Cardiac Arrest
Cardiovascular Disease
Chest Pain
Cholesterol (high)
Circulation (poor)
Colon (atonic)
Constipation (adults)
Convulsions
Cramps (leg)
Cramps (menstrual)
Cramps and Spasms
Depression
Diabetes
Digestion (poor)
Dizziness
Dysmenorrhea
Emotional Sensitivity
Endurance (lack of)
Energy (lack of)
Epilepsy
Exercise
Fatigue
Fibromyalgia Syndrome
Gastritis
Headache (cluster)
Headache (general)
Headache (tension)
Hearing Loss
Heart (weakness)
Heart Fibrillation or Palpitations
Hypertension
Insomnia
Mental Illness
Migraine
Mood Swings
Muscle Tone (lack of)
Nerve Damage
Nervous Exhaustion
Nervousness
Neurosis
Numbness
Osteoporosis
Oxygen Deficiency
Pain (general remedies for)
Paralysis
Pets (supplements for)
PMS (general)
PMS Type A
PMS Type C
PMS Type D
PMS Type H
PMS Type P
Post Partum Depression
Post Partum Weakness
Post Traumatic Stress Disorder
Pregnancy (herbs and supplements for)
Progesterone (low)
Psoriasis
Restless Leg Syndrome
Rhinitis
Seasonal Affective Disorder
Seizures
Senility
Shock
Skin (dry and/or flaky)
Skin Care (general)
Sleep (restless and disturbed)
Stress
Sugar Cravings
Surgery (healing from)
Surgery (preparation for)
Tachycardia
Tension
Testosterone (low)
Tetanus
Thinking (cloudy)
Tics
Tinnitus
TMJ
Tooth Decay
Toxemia
Triglycerides (high)
Twitching
Wasting
Wheezing
Worry
Wounds and Sores

Products containing magnesium

Health Concerns

Brands

Evidence supporting the use of: Magnesium
For the health condition: Depression

Table of Contents

Synopsis

Other ingredients used for Depression

Other health conditions supported by magnesium

Products containing magnesium

Health Concerns

Brands

Evidence supporting the use of: MagnesiumFor the health condition: Depression

Table of Contents

Synopsis

Other ingredients used for Depression

Other health conditions supported by magnesium

Products containing magnesium

Evidence supporting the use of: Magnesium
For the health condition: Depression