Evidence supporting the use of: Marijuana
For the health condition: Depression

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Marijuana (cannabis) has been explored for its potential role in alleviating symptoms of depression, primarily due to its psychoactive compounds such as THC (tetrahydrocannabinol) and CBD (cannabidiol). Some scientific studies suggest that these cannabinoids may influence mood-regulating neurotransmitters in the brain, such as serotonin and dopamine, which are often implicated in depression. Small-scale observational studies and patient reports indicate that some individuals experience short-term mood improvement after cannabis use. However, evidence from large, well-designed clinical trials remains limited and inconsistent.

Systematic reviews, including a 2020 review in JAMA Network Open, have concluded that while some people with depression report subjective relief from symptoms with cannabis, there is insufficient high-quality evidence to recommend its use as a primary treatment for depression. The potential for temporary mood elevation is offset by findings that chronic or heavy cannabis use may worsen depressive symptoms or increase the risk of developing depression, especially in young users or those with a predisposition. Leading psychiatric organizations generally advise caution or recommend against medical marijuana for depression due to concerns about dependency, cognitive effects, and the lack of robust efficacy data.

In summary, while there is some scientific investigation and anecdotal support for marijuana’s use in depression, the current strength of evidence is low and not sufficient for broad clinical endorsement. More rigorous research is needed to clarify its risks and benefits.

More about Marijuana
More about Depression

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ashwagandha
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DPA (docosapentaenoic acid)
eleuthero
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epigallocatechin gallate (EGCG)
fish oil
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flavonols
folate
gardenia
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phenolic acids
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Products containing Marijuana

We currently have no products on Vitabase that contain this ingredient.