Evidence supporting the use of: Marine lipid
For the health condition: Depression

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Marine lipids, particularly those rich in omega-3 polyunsaturated fatty acids (PUFAs) such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), have been extensively studied for their potential role in supporting and treating depression. Several meta-analyses and randomized controlled trials (RCTs) have found that supplementation with omega-3 fatty acids, especially those with higher EPA content, may have a modest but statistically significant effect in reducing depressive symptoms, especially in individuals with diagnosed major depressive disorder (MDD). The proposed mechanisms include anti-inflammatory effects, modulation of neurotransmitter pathways (such as serotonin and dopamine), and influences on neuronal membrane fluidity and function.

Guidelines from some psychiatric associations now recognize omega-3 supplementation as an adjunctive treatment for depression. However, the strength of evidence is considered moderate (rated here as 3/5): results across studies are mixed, with some trials showing benefit and others finding no effect, possibly due to differences in dosage, EPA:DHA ratio, study populations, or baseline omega-3 status. Notably, the greatest benefit appears to be for EPA-predominant formulas and in people with more severe depression. Omega-3 supplementation is generally well-tolerated with a favorable safety profile.

In conclusion, marine lipids, particularly omega-3 fatty acids, have scientific evidence supporting their use as a supplementary approach for depression, though they should not replace standard medical care. Further high-quality research is needed to clarify optimal dosing, formulations, and target populations.

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bergamot
beta caryophyllene
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cordyceps
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DPA (docosapentaenoic acid)
eleuthero
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fish oil
fish protein
flavonols
folate
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ginger
ginkgo biloba
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hemp oil
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lavender
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magnesium
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omega-3 fatty acids
phenolic compounds
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phytocannabinoids
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pregnenolone
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butyric acid
quercetin
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