Evidence supporting the use of: Mushroom (various)
For the health condition: Depression

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

There is emerging scientific evidence that certain mushrooms, particularly Psilocybe species (containing the psychedelic compound psilocybin), may have therapeutic potential for depression. Clinical trials have indicated that psilocybin-assisted therapy can produce rapid and sustained reductions in depressive symptoms, even in cases of treatment-resistant depression. For example, a 2020 randomized clinical trial published in JAMA Psychiatry found that psilocybin, when administered with psychological support, led to significant decreases in depression scores compared to a waitlist control. Other studies have demonstrated similar effects, with benefits persisting for weeks or months after treatment. The proposed mechanisms include increased neuroplasticity, altered brain network connectivity, and facilitation of emotional processing.

However, it is important to note that these effects are specific to psilocybin-containing mushrooms and not to culinary varieties like shiitake or button mushrooms. Additionally, psilocybin treatment is not yet widely available or approved outside of research settings, and more large-scale, long-term studies are needed to fully establish efficacy and safety. While traditional use of psychoactive mushrooms for spiritual and healing purposes exists in some cultures, the current interest in depression treatment is primarily driven by scientific research.

More about Mushroom (various)
More about Depression

Other ingredients used for Depression

5-Hydroxytryptophan (5-HTP)
Acetyl L-carnitine
algal oil
alpha-linolenic acid (ALA)
amino acids
anchovies
anthocyanins
ashwagandha
waterhyssop
basil
bergamot
beta caryophyllene
bifidobacterium longum
black tea
Indian frankincense
bасора
caffeine
cannabis sativa oil
chamomile
Chinese salvia root
choline
citicoline
clove
coenzyme Q10 (CoQ10)
cordyceps
creatine monohydrate
turmeric
curcumin
damiana
DHA (docosahexaeonic acid)
DHEA (dehydroepiandrosterone)
DPA (docosapentaenoic acid)
eleuthero
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fish oil
fish protein
flavonols
folate
gardenia
ginger
ginkgo biloba
ginseng
gotu kola
greek mountain tea
green tea
hemp oil
Indian tinospora
inositol
jujube
krill oil
l-5-methyltetrahydrofolate glucosamine salt (5-MTHF)
L-carnosine
L-glycine
L-methionine
L-phenylalanine
L-theanine
L-tryptophan
l-tyrosine
lactium casein decapeptide
lavender
lion's mane
lithium orotate
liquid liver fractions
luteolin
maca
mackerel
magnesium
magnolia
marine lipid
matcha
melatonin
moringa
muira puama
n-acetyl-cysteine (NAC)
Acetyl-L-Tyrosine
omega-3 fatty acids
phenolic compounds
phosphatidylserine
phospholipids
phytocannabinoids
polygala root
pomegranate
prebiotic blend (proprietary)
pregnenolone
protein
butyric acid
quercetin
reishi mushroom
resveratrol
rhodiola
rose oil
rosemary
saffron
sage
SAMe (s-adenosyl-l-methionine disulfate p-toluensulfate)
sardines
sceletium
selenium
specialized pro-resolving mediators (SPMs)
sphaeranthus indicus
spirulina
tongkat ali
Almond fruit
valerian root
velvet bean
vitamin B
vitamin B12
vitamin B6
vitamin C
vitamin D
vitamin D3
whey protein
zinc
suma
gastrodia
mugwort
alpinia galangal
commiphora
blackboard tree
caesalpinia crista
peony
lingzhi
lemongrass
kanna
cistanche
dodder
morinda
royal jelly
polyphenols
trace minerals
St. John's Wort
yerba mate
hypothalamus
cocoa
thyroid substance
star of Bethlehem
5-methyltetrahydrofolate glucosamine
7,8-Dihydroxyflavone
Arginine Creatine
Ardisia
Angelica
Apigenin
Albizia
Agmatine
Agarwood
Alpha lactalbumin
Asteracea
Algal protein
Aniracetam
Amor seco
Betony
Baikal Skullcap
Broussonetia
Beta-hydroxybutyrate
Biopterin
Butea monosperma
Beef liver
Bacopin
Brahmi
Bacopa
Bee products
bacoside
Baicalin
Black Hellebore
Biogenic amine
Camellia sinensis
Coconut
Caryophyllene
Monkey Flower
Crocin
Clary sage
Catalpol
Codonopsis
Curcuminoid
Citrus
Chinese Raisintree
Curcumen
Cymbopogon Martini
Centella asiatica
Chocolate
Creatine
Curcuma
Cowslip
Cannabidiol
Convolvulus prostratus
Convolvulus Pluricaulis
cola nut
Canscora
Cannabichromene
Docosahexaenoic Acid
D-phenylalanine
DHEA
Devil's Club
Dopamine
Egg
Eicosatetraenoic acid
Eicosapentaenoic Acid
Estrogen
Folinic Acid
Folic Acid
Flavonoids
Fragrant Rosewood
Fish
Fatty acids
Fungus
Frankincense
Guanidinoacetic acid
Ginsenosides
Griffonia simplicifolia
Gypenoside
Growth factors
Glutamate
Glycine
Gastrodin
Honokiol
Hypericin
Hellebore
Hypericum
hyperforin
Helicteres isora
Hericium mushroom
Hemp
isoliquiritigenin
Long Pepper
icariin
Indian Fagonia
Inositol phosphate
jasmine
Jatamansi
Kokilaksha
lemon balm
Lebbek
Ligustilides
Limonene
Lavandin
Lycopodium
Large-Leaved Linden
Little ironweed
Lactalbumin
Lactoglobulin
Linalool
Lipids
Methylcobalamin
Marine Protein
Milk Protein
Methylxanthine
Mimosa
Meadow sage
Marine fat
Magnolol
Mulungu
Mesembrine
Nardostachys
Nigella Seed
Nymphaea caerulea
Nymphaea nouchali
Nutmeg
Oroxylum indicum
Onosma bracteatum
Oxindole alkaloids
Osthole
Phosphocreatine
Pyrroloquinoline Quinone
Phenylethylamine (PEA)
Pulsatilla
Patchouli oil
Pentacyclic triterpenoids
Polyunsaturated Fat
Piper nigrum
Polygonatum
Paeoniflorin
Physalis angulata
Poly-thyronine
Phytoestrogens
Polygala
Petiveria
Purple Monkeyflower
Palmitoylethanolamide (PEA)
Rue
Rosavins
Rosabin
Rosmarinic Acid
Rubiaceae
Rose
Sichuan Lovage
Schizochytrium Oil
Sete sangrias
Spikenard
Scleranthus annus
Salvia
Sensitive Plant
Sulbutiamine
Shellfish
Salmon Oil
Salidroside
Safed musli
Shankhpushpi
Sandalwood
Stereospermum
Shilajit
Saffranal
Sarcosine
Sweet Orange alcohol
Terpenoids
Tea
Thymoquinone
Tumerone
Trichilia catigua
Tetrahydropalmatine
Uncaria
Uridine
Vetiver
Vervain
Withanolides
Wogonin
Wulinshen
walnut
Xanthophyll
Xylaria nigripes
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yohimbine
Ylang ylang
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Zingiberene

Products containing Mushroom (various)

We currently have no products on Vitabase that contain this ingredient.