Evidence supporting the use of: N-Acetyl Cysteine
For the health condition: Depression

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

N-Acetyl Cysteine (NAC) has been investigated as an adjunctive treatment for depression based on its antioxidant and glutamatergic-modulating properties. Several randomized controlled trials (RCTs) and meta-analyses have explored its efficacy. The rationale for its use is rooted in the oxidative stress and glutamate dysregulation hypotheses of depression. NAC is a precursor to glutathione, a major antioxidant in the brain, and may help restore redox balance and regulate neurotransmitter systems implicated in mood disorders.

Evidence from clinical studies is mixed but promising. A 2016 meta-analysis published in Journal of Clinical Psychiatry concluded that NAC supplementation (usually at 2,000–3,000 mg/day) was associated with a moderate reduction in depressive symptoms, particularly as an adjunct to standard treatments. However, the number of high-quality RCTs is limited, and some studies have reported minimal or no benefit. Safety and tolerability are generally good, contributing to its appeal as an adjunctive therapy.

In summary, while NAC is not a first-line treatment for depression, there is moderate scientific evidence suggesting it may be beneficial as an adjunct, especially in individuals with treatment-resistant depression or those with comorbid oxidative stress-related conditions. More large-scale, high-quality trials are needed to firmly establish its efficacy and optimal use in depressive disorders.

More about N-Acetyl Cysteine
More about Depression

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amino acids
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bergamot
beta caryophyllene
bifidobacterium longum
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clove
coenzyme Q10 (CoQ10)
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damiana
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DPA (docosapentaenoic acid)
eleuthero
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fish oil
fish protein
flavonols
folate
gardenia
ginger
ginkgo biloba
ginseng
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green tea
hemp oil
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lavender
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maca
mackerel
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magnolia
marine lipid
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moringa
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n-acetyl-cysteine (NAC)
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omega-3 fatty acids
phenolic compounds
phosphatidylserine
phospholipids
phytocannabinoids
polygala root
pomegranate
prebiotic blend (proprietary)
pregnenolone
protein
butyric acid
quercetin
reishi mushroom
resveratrol
rhodiola
rose oil
rosemary
saffron
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hyperforin
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isoliquiritigenin
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Products containing N-Acetyl Cysteine

We currently have no products on Vitabase that contain this ingredient.