Evidence supporting the use of: Pentacyclic Oxindole Alkaloids
For the health condition: Depression

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Synopsis

Source of validity: Traditional
Rating (out of 5): 1

Pentacyclic oxindole alkaloids are a class of compounds primarily found in the plant Uncaria tomentosa, commonly known as Cat's Claw. Traditionally, Cat's Claw has been used in South American herbal medicine for a variety of ailments, including inflammatory conditions and immune support. Its use for mood disorders or depression, however, is not a common or well-documented practice in traditional medicine, though there are occasional anecdotal reports of mood enhancement as part of broader health claims.

From a scientific perspective, there is very limited evidence to support the use of pentacyclic oxindole alkaloids for depression. Most studies focus on their immunomodulatory, anti-inflammatory, and antioxidant properties, rather than direct neurochemical or psychological effects. Only a few animal studies and in vitro experiments suggest possible neuroprotective or neuromodulatory effects, but these findings have not been translated into clinical trials or robust human data. No high-quality, peer-reviewed studies have established a clear antidepressant effect or mechanism for these compounds in humans.

In summary, while pentacyclic oxindole alkaloids are occasionally mentioned in traditional contexts for general wellness, their specific use for depression is mostly anecdotal and not well-supported by either traditional records or scientific research. The evidence base for their efficacy in treating or supporting depression is minimal to non-existent at this time.

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Products containing Pentacyclic Oxindole Alkaloids

We currently have no products on Vitabase that contain this ingredient.