Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Specialized pro-resolving mediators (SPMs) are a class of bioactive lipids derived from omega-3 and omega-6 fatty acids, including resolvins, protectins, and maresins. They are primarily recognized for their role in actively resolving inflammation. Recent scientific interest has considered the link between inflammation and depression, as substantial evidence suggests that chronic low-grade inflammation may contribute to the pathophysiology of depressive disorders in some individuals. Preclinical studies have shown that SPMs can reduce neuroinflammation and have neuroprotective effects in animal models, which may theoretically benefit mood regulation.

However, clinical evidence in humans is still limited. A few small-scale pilot studies and case reports have explored SPM supplementation in patients with depression, often secondary to other inflammatory conditions, and have reported modest improvements in mood symptoms. Some mechanistic studies indicate that SPMs may dampen pro-inflammatory cytokine activity and modulate microglial function, which is relevant to depression’s inflammatory theory.

Overall, while there is a rational scientific basis and some preliminary data supporting the potential of SPMs in depression, the evidence is still at an early stage, with a lack of large, well-controlled clinical trials. Thus, SPM use for depression is not yet a standard or widely accepted treatment, and its efficacy remains to be robustly established.

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Products containing specialized pro-resolving mediators (SPMs)

Douglas Laboratories QÜELL® FISH OIL DHA Ultra SPM