Evidence supporting the use of: Thymoquinone
For the health condition: Depression

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Thymoquinone, the main bioactive component of Nigella sativa (black seed), has been investigated in several preclinical studies for its potential antidepressant effects. Most of the evidence comes from animal models, where thymoquinone has demonstrated antidepressant-like activity, possibly due to its antioxidant, anti-inflammatory, and neuroprotective properties. Mechanistically, studies suggest that thymoquinone may modulate neurotransmitter levels (such as serotonin and dopamine), reduce oxidative stress, and inhibit pro-inflammatory cytokines in the brain, all of which are implicated in the pathophysiology of depression.

However, the clinical evidence supporting the use of thymoquinone or Nigella sativa extracts for depression in humans is sparse. A few small-scale human studies and pilot trials with Nigella sativa (not isolated thymoquinone) have reported improvements in mood or reductions in symptoms related to anxiety and depression, but these studies are limited in size, design quality, and sometimes do not isolate thymoquinone as the active compound. Thus, while there is a scientific rationale and some preliminary evidence from preclinical and limited clinical studies, robust clinical trials in humans are lacking. Therefore, the evidence level is rated as 2 (weak preliminary scientific support), and thymoquinone should not be considered a proven or primary treatment for depression at this time.

More about Thymoquinone
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Products containing Thymoquinone

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