Evidence supporting the use of: Vitamin B1
For the health condition: Depression

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin B1, also known as thiamine, has been investigated for its potential role in supporting mental health, including depression. Thiamine is essential for brain function as it helps convert glucose into energy and is involved in neurotransmitter synthesis. Deficiency in thiamine can lead to neurological and psychiatric symptoms, including irritability, fatigue, and, in severe cases, Wernicke-Korsakoff syndrome, which features profound cognitive and mood disturbances. Several observational studies have found that individuals with depression are more likely to have lower thiamine levels. Some small clinical trials and case reports suggest that supplementation with thiamine may improve mood in people with deficiency or suboptimal levels, particularly in elderly or malnourished populations. However, while there is a biological rationale and some limited clinical evidence for thiamine supplementation improving depressive symptoms when deficiency is present, robust randomized controlled trials (RCTs) in the general population with depression are lacking. The current scientific consensus is that thiamine supplementation may be beneficial in individuals with confirmed or suspected deficiency, but there is insufficient evidence to support its widespread use as a primary treatment for depression in otherwise healthy individuals. Overall, the use of Vitamin B1 for depression has some scientific basis, but the quality and quantity of evidence are limited, meriting a modest evidence rating.

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Other ingredients used for Depression

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algal oil
alpha-linolenic acid (ALA)
amino acids
anchovies
anthocyanins
ashwagandha
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basil
bergamot
beta caryophyllene
Bifidobacterium longum
black tea
Indian frankincense
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caffeine
Cannabis sativa oil
chamomile
Chinese salvia root
choline
citicoline
clove
coenzyme Q10 (CoQ10)
cordyceps
creatine monohydrate
turmeric
curcumin
damiana
DHA (docosahexaenoic acid)
DHEA (dehydroepiandrosterone)
DPA (docosapentaenoic acid)
eleuthero
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fish oil
fish protein
flavonols
folate
gardenia
ginger
ginkgo biloba
ginseng
gotu kola
Greek mountain tea
green tea
hemp oil
Indian tinospora
inositol
jujube
krill oil
l-5-methyltetrahydrofolate glucosamine salt (5-MTHF)
L-carnosine
L-glycine
L-methionine
L-phenylalanine
L-theanine
L-tryptophan
l-tyrosine
lactium casein decapeptide
lavender
lion's mane
lithium orotate
liquid liver fractions
luteolin
maca
magnesium
magnolia
Marine lipid
Matcha
Melatonin
Moringa
Muira puama
N-acetyl-cysteine (NAC)
Acetyl-L-Tyrosine
omega-3 fatty acids
phenolic compounds
phosphatidylserine
phospholipids
phytocannabinoids
polygala root
pomegranate
prebiotic blend (proprietary)
pregnenolone
protein
butyric acid
quercetin
reishi mushroom
resveratrol
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rose oil
rosemary
saffron
sage
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vitamin B12
vitamin B6
vitamin C
vitamin D
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suma
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catalpol
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chocolate
creatine
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cola nut
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cannabichromene
docosahexaenoic Acid
D-phenylalanine
DHEA
devil\'s club
dopamine
egg
Eicosatetraenoic acid
eicosapentaenoic acid
estrogen
folinic acid
folic acid
flavonoids
fragrant rosewood
fish
fatty acids
fungus
frankincense
guanidinoacetic acid
Ginsenosides
Griffonia simplicifolia
Gypenoside
Glutamate
Glycine
gastrodin
Honokiol
Hypericin
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Hypericum
hyperforin
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hericium mushroom
hemp
isoliquiritigenin
long pepper
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inositol phosphate
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limonene
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little ironweed
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magnolol
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Products containing Vitamin B1

We currently have no products on Vitabase that contain this ingredient.