Evidence supporting the use of: Vitamin B12 (5-deoxyadenosylcobalamin)
For the health condition: Depression
Synopsis
Source of validity: Scientific
Rating (out of 5): 2
Vitamin B12 (as 5-deoxyadenosylcobalamin and other cobalamin forms) has scientific connections to mood regulation and depression, though the evidence is limited and not definitive. Vitamin B12 is vital for neurological function, DNA synthesis, and methylation processes, all of which are implicated in neurotransmitter production, such as serotonin and dopamine. Deficiency in B12 has been associated with neuropsychiatric symptoms, including mood disturbances and depression, particularly in elderly populations and strict vegetarians or vegans, who are at greater risk for deficiency.
A number of observational studies have reported an association between low B12 levels and increased risk or severity of depressive symptoms. Some interventional studies and case reports indicate that correcting B12 deficiency may improve depressive symptoms, especially when deficiency is pronounced. However, large-scale randomized clinical trials in individuals with normal B12 levels have not consistently shown benefit for B12 supplementation in treating depression.
Medical guidelines generally recommend screening for B12 deficiency in people with depression, especially if they are at risk for deficiency, but there is insufficient evidence to support routine use of B12 supplements for depression in those with adequate levels. In summary, while there is a biological rationale and some clinical evidence supporting the role of B12 in mood regulation, robust evidence for its effectiveness as a treatment for depression is lacking.
More about Vitamin B12 (5-deoxyadenosylcobalamin)
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algal oil
alpha-linolenic acid (ALA)
amino acids
anchovies
anthocyanins
ashwagandha
waterhyssop
basil
bergamot
beta caryophyllene
bifidobacterium longum
black tea
Indian frankincense
bасора
caffeine
cannabis sativa oil
chamomile
Chinese salvia root
choline
citicoline
clove
coenzyme Q10 (CoQ10)
cordyceps
creatine monohydrate
turmeric
curcumin
damiana
DHA (docosahexaeonic acid)
DHEA (dehydroepiandrosterone)
DPA (docosapentaenoic acid)
eleuthero
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fish oil
fish protein
flavonols
folate
gardenia
ginger
ginkgo biloba
ginseng
gotu kola
greek mountain tea
green tea
hemp oil
Indian tinospora
inositol
jujube
krill oil
l-5-methyltetrahydrofolate glucosamine salt (5-MTHF)
l-carnosine
l-glycine
l-methionine
l-phenylalanine
l-theanine
l-tryptophan
l-tyrosine
lactium casein decapeptide
lavender
lion's mane
lithium orotate
liquid liver fractions
luteolin
maca
mackerel
magnesium
magnolia
marine lipid
matcha
melatonin
moringa
muira puama
n-acetyl-cysteine (NAC)
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omega-3 fatty acids
phenolic acids
phosphatidylserine
phospholipids
phytocannabinoids
polygala root
pomegranate
prebiotic blend (proprietary)
pregnenolone
protein
butyric acid
quercetin
reishi mushroom
resveratrol
rhodiola
rose oil
rosemary
saffron
sage
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sardines
sceletium
selenium
specialized pro-resolving mediators (SPMs)
sphaeranthus indicus
spirulina
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almond fruit
valerian root
velvet bean
vitamin B
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vitamin B6
vitamin C
vitamin D
vitamin D3
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zinc
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gastrodia
mugwort
alpinia galangal
commiphora
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trace minerals
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hypothalamus
cocoa
thyroid substance
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Creatine
Curcuma
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cola nut
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Cannabichromene
Docosahexaenoic Acid
D-phenylalanine
DHEA
Devil's Club
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Eicosatetraenoic acid
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Estrogen
Folic Acid
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jasmine
Little ironweed
Milk Protein
Mimosa
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walnut
yohimbine
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Other health conditions supported by Vitamin B12 (5-deoxyadenosylcobalamin)
AnemiaDementia
Depression
Fatigue
Memory and Brain Function
Nerve Damage
Peripheral Neuropathy
Pernicious Anemia