Evidence supporting the use of: Vitamin B12 (methylcobalamin)
For the health condition: Depression

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin B12 (methylcobalamin) has some scientific support for its use in depression, but the evidence is not robust. B12 is essential for neurological function and the synthesis of neurotransmitters, including serotonin and dopamine, which are involved in mood regulation. Deficiency in B12 can lead to neuropsychiatric symptoms, including depression, and several observational studies have found that individuals with low B12 levels are at increased risk for depressive disorders. Some clinical trials suggest that supplementation with B12 (often alongside folate and other B vitamins) can improve depressive symptoms, particularly in people who are deficient. However, in people with normal B12 status, the benefit is far less clear. The evidence base consists mainly of observational studies, small randomized controlled trials, and meta-analyses with mixed results. Major treatment guidelines do not recommend B12 supplementation as a primary therapy for depression except in cases of documented deficiency. In summary, while there is some scientific rationale and limited clinical evidence supporting B12 supplementation for depression—especially in deficient individuals—the overall quality and consistency of the evidence are moderate at best.

More about Vitamin B12 (methylcobalamin)
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Other ingredients used for Depression

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acetyl l-carnitine
algal oil
alpha-linolenic acid (ALA)
amino acids
anchovies
anthocyanins
ashwagandha
waterhyssop
basil
bergamot
beta caryophyllene
bifidobacterium longum
black tea
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caffeine
cannabis sativa oil
chamomile
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choline
citicoline
clove
coenzyme Q10 (CoQ10)
cordyceps
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turmeric
curcumin
damiana
DHA (docosahexaeonic acid)
DHEA (dehydroepiandrosterone)
DPA (docosapentaenoic acid)
eleuthero
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fish oil
fish protein
flavonols
folate
gardenia
ginger
ginkgo biloba
ginseng
gotu kola
greek mountain tea
green tea
hemp oil
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inositol
jujube
krill oil
l-5-methyltetrahydrofolate glucosamine salt (5-MTHF)
l-carnosine
l-glycine
l-methionine
l-phenylalanine
l-theanine
l-tryptophan
l-tyrosine
lactium casein decapeptide
lavender
lion's mane
lithium orotate
liquid liver fractions
luteolin
maca
mackerel
magnesium
magnolia
marine lipid
matcha
melatonin
moringa
muira puama
n-acetyl-cysteine (NAC)
Acetyl-L-Tyrosine
omega-3 fatty acids
phenolic acids
phosphatidylserine
phospholipids
phytocannabinoids
polygala root
pomegranate
prebiotic blend (proprietary)
pregnenolone
protein
butyric acid
quercetin
reishi mushroom
resveratrol
rhodiola
rose oil
rosemary
saffron
sage
SAMe (s-adenosyl-l-methionine disulfate p-toluensulfate)
sardines
sceletium
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vitamin C
vitamin D
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Estrogen
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jasmine
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Products containing Vitamin B12 (methylcobalamin)

We currently have no products on Vitabase that contain this ingredient.