Evidence supporting the use of: Vitamin B9 (calcium methylfolate)
For the health condition: Depression

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Vitamin B9, particularly in the form of L-methylfolate (often as calcium methylfolate), has scientific validation for its use as an adjunctive treatment in depression, especially in individuals with low folate levels or certain genetic polymorphisms (e.g., MTHFR mutations) that impair folate metabolism. L-methylfolate is a bioactive form of folate that crosses the blood-brain barrier and participates in the synthesis of neurotransmitters such as serotonin, dopamine, and norepinephrine, which are implicated in mood regulation. Several randomized controlled trials and meta-analyses have demonstrated that adjunctive L-methylfolate can enhance the efficacy of antidepressant medications in patients with major depressive disorder (MDD) who have an inadequate response to first-line treatments. For instance, a pivotal study published in the American Journal of Psychiatry (Papakostas et al., 2012) found that 15 mg/day L-methylfolate significantly improved depressive symptoms compared to placebo as an adjunct to SSRIs. The effect is more pronounced in subgroups with low baseline folate or elevated inflammatory markers. However, the evidence is not universally robust, with some studies reporting modest or non-significant effects, and the benefit seems greatest in select populations rather than all patients with depression. Overall, the use of calcium methylfolate for depression is supported by scientific evidence, particularly as an adjunct in treatment-resistant cases, but it is not considered a first-line standalone therapy.

More about Vitamin B9 (calcium methylfolate)
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Other ingredients used for Depression

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acetyl l-carnitine
algal oil
alpha-linolenic acid (ALA)
amino acids
anchovies
anthocyanins
ashwagandha
waterhyssop
basil
bergamot
beta caryophyllene
bifidobacterium longum
black tea
Indian frankincense
bасора
caffeine
cannabis sativa oil
chamomile
Chinese salvia root
choline
citicoline
clove
coenzyme Q10 (CoQ10)
cordyceps
creatine monohydrate
turmeric
curcumin
damiana
DHA (docosahexaeonic acid)
DHEA (dehydroepiandrosterone)
DPA (docosapentaenoic acid)
eleuthero
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fish oil
fish protein
flavonols
folate
gardenia
ginger
ginkgo biloba
ginseng
gotu kola
greek mountain tea
green tea
hemp oil
Indian tinospora
inositol
jujube
krill oil
l-5-methyltetrahydrofolate glucosamine salt (5-MTHF)
l-carnosine
l-glycine
l-methionine
l-phenylalanine
l-theanine
l-tryptophan
l-tyrosine
lactium casein decapeptide
lavender
lion's mane
lithium orotate
liquid liver fractions
luteolin
maca
mackerel
magnesium
magnolia
marine lipid
matcha
melatonin
moringa
muira puama
n-acetyl-cysteine (NAC)
Acetyl-L-Tyrosine
omega-3 fatty acids
phenolic acids
phosphatidylserine
phospholipids
phytocannabinoids
polygala root
pomegranate
prebiotic blend (proprietary)
pregnenolone
protein
butyric acid
quercetin
reishi mushroom
resveratrol
rhodiola
rose oil
rosemary
saffron
sage
SAMe (s-adenosyl-l-methionine disulfate p-toluensulfate)
sardines
sceletium
selenium
specialized pro-resolving mediators (SPMs)
sphaeranthus indicus
spirulina
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valerian root
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vitamin B
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vitamin C
vitamin D
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zinc
suma
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alpinia galangal
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hypothalamus
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bacoside
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Curcuma
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Cannabidiol
Convolvulus prostratus
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cola nut
Canscora
Cannabichromene
Docosahexaenoic Acid
D-phenylalanine
DHEA
Devil's Club
Dopamine
Egg
Eicosatetraenoic acid
Eicosapentaenoic Acid
Estrogen
Folic Acid
Flavonoids
Glycine
jasmine
Little ironweed
Milk Protein
Mimosa
Phenylethylamine (PEA)
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yohimbine
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Products containing Vitamin B9 (calcium methylfolate)

We currently have no products on Vitabase that contain this ingredient.