Evidence supporting the use of: Caryophyllene
For the health condition: Dermatitis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Caryophyllene is a bicyclic sesquiterpene found in essential oils of numerous plants, notably clove, black pepper, and cannabis. Its potential for supporting or treating dermatitis is primarily based on scientific evidence from preclinical studies. Caryophyllene is known to selectively bind to the cannabinoid receptor type 2 (CB2), which is associated with anti-inflammatory and analgesic effects. Several in vitro and animal studies have demonstrated that caryophyllene can reduce inflammation and modulate immune responses in skin tissues. For example, a 2014 study published in the journal European Journal of Pain reported that caryophyllene reduced inflammatory responses in a mouse model of contact dermatitis via CB2 receptor activation. Other studies have observed caryophyllene’s ability to decrease pro-inflammatory cytokines and support barrier function in skin models.

However, robust clinical trials in humans are lacking, and most of the evidence comes from animal or cell-based studies. There are also a few traditional uses of caryophyllene-containing plants for skin conditions, but the modern rationale hinges on its pharmacological properties and preclinical research. Thus, while the scientific basis is promising, the overall evidence remains limited and not yet conclusive for widespread therapeutic use in human dermatitis.

More about caryophyllene
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alpha-pinene
beeswax
beta caryophyllene
bisabolol
black currant
black walnut
burdock
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chamomile
coating
turmeric
forsythia
garlic bulb
ginger
gotu kola
green tea
hemp oil
hyaluronic acid
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lauric acid
Niacinamide (vitamin B3)
oregon grape
phenolic compounds
plantain
pomegranate
purified silver
quercetin
resveratrol
riboflavin (vitamin B2)
rosemary
schizonepeta
scrophularia root
specialized pro-resolving mediators (SPMs)
Sphaeranthus indicus
vitamin A
vitamin D
vitamin E
Zinc
chickweed
xanthium (cockleburs)
Mugwort
Neem tree
commiphora
siler root
oriental arborvitae
birch
polyphenols
fulvic acid
eucalyptus
Menthol oil
melaleuca alternifolia
geranium
avens
alpha-terpineol
azelaic acid
Ardisia
anamu
Allantoin
Asteraceae
argan nut oil
bee propolis
babchi
Baphicacanthus cusia
Bidens pilosa
bishop\'s weed
Boswellic Acid
Butea monosperma
Barleria
bisabolene
bee products
Bombax
Bassia scoparia
coconut
Centella triterpenes
caryophyllene
Calendula
chlorophyllin
coconut oil
colloid
carvacrol
Curcuminoid
Chinese raisintree
curcumen
Centella asiatica
Centipeda
Curcuma
cannabidiol
Carthamus
copaiba oil
cannabigerol
chrysophanics
Dianthus
Epidermal Growth Factor
Eclipta
emu oil
Euphorbia
ethyl linoleate
flavonoids
fang-feng
fatty acids
Ficus simplicissima
fibroblast growth factor
gallic acid
Gnaphalium
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Growth factors
Glechoma hederacea
gallotannin
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heal-all
Hydrocolloid
henna
Himalaya berry
hemp
iridoid glycosides
Indian fagonia
jojoba oil
Kokilaksha
Litsea
lichen
Laggera pterodonta
linseed oil
Lantana camara
Leptospermum scoparium
Labdanum
mallow
Melia
Malva sylvestris
mangostin
Mahonia
Milkweed
Marine colloids
marigold
Marking Nut Tree
Macaranga indica
Nigella seed
Oxystelma
Propolis
Phyllanthus
Pentacyclic triterpenoids
Paris polyphylla
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rue
rosmarinic acid
reed herb
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Products containing caryophyllene

We currently have no products on Vitabase that contain this ingredient.