Evidence supporting the use of: Epidermal Growth Factor
For the health condition: Dermatitis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Epidermal Growth Factor (EGF) has some scientific validation for its use in supporting or treating dermatitis, particularly in the context of atopic dermatitis and wound healing. EGF is a polypeptide that stimulates cell growth, proliferation, and differentiation by binding to its receptor, EGFR, on the cell surface. Several studies and clinical trials have investigated topical application of EGF in patients with various skin conditions, including dermatitis. For example, randomized controlled trials have demonstrated that topical EGF can accelerate healing of skin lesions, improve barrier function, and reduce inflammation in models of atopic dermatitis and other skin injuries. A 2018 study published in the "Annals of Dermatology" found that EGF ointment aided the repair of skin barrier function and reduced symptoms in patients with atopic dermatitis. Another 2015 study reported improved wound healing and reduced inflammatory markers in animal models treated with EGF.

However, while these results are promising, the body of evidence is not yet extensive or universally conclusive, and EGF is not a standard first-line therapy for dermatitis. Most studies have small sample sizes or are preclinical, and long-term safety data are limited. Nevertheless, the mechanism of action and available research provide a scientific rationale for its use as an adjunctive therapy in certain cases of dermatitis, especially where wound healing is impaired. More large-scale, high-quality clinical trials are needed to fully establish EGF’s efficacy and safety profile for routine treatment of dermatitis.

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alpha-pinene
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azelaic acid
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beta caryophyllene
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black walnut
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burdock
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cannabidiol
cannabigerol
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Carthamus
carvacrol
caryophyllene
Centella asiatica
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Centipeda
chamomile
chickweed
Chinese raisintree
chlorophyllin
chrysophanics
coconut
coconut oil
colloid
commiphora
copaiba oil
Curcuma
curcumen
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Dianthus
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emu oil
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ethyl linoleate
eucalyptus
Euphorbia
fang-feng
fatty acids
fibroblast growth factor
Ficus simplicissima
flavonoids
forsythia
fulvic acid
gallic acid
gallotannin
garlic bulb
geranium
ginger
Glechoma hederacea
glyceryl monolaurate
Glycyrrhetinic acid
Gnaphalium
gotu kola
green tea
heal-all
hemp
hemp oil
henna
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hyaluronic acid
Hydrocolloid
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iridoid glycosides
jojoba oil
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lauric acid
Leptospermum scoparium
lichen
linseed oil
Litsea
Macaranga indica
Mahonia
mallow
Malva sylvestris
mangostin
marigold
Marine colloids
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melaleuca alternifolia
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Milkweed
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oriental arborvitae
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phenolic compounds
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pomegranate
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quercetin
resveratrol
riboflavin (vitamin B2)
rosemary
rosmarinic acid
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schizonepeta
scrophularia root
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Products containing Epidermal Growth Factor

We currently have no products on Vitabase that contain this ingredient.