Flavonoids, a diverse group of plant polyphenols, have been investigated for their potential therapeutic effects in dermatology, including the treatment and support of dermatitis. Scientific evidence suggests that certain flavonoid mixtures possess anti-inflammatory, antioxidant, and immunomodulatory properties, which may be beneficial in managing dermatitis. Several in vitro and in vivo studies have demonstrated that flavonoids can inhibit the release of pro-inflammatory mediators such as TNF-α, IL-6, and histamine from immune cells, which are implicated in the pathogenesis of atopic and contact dermatitis.

Clinical studies are limited but promising. For example, topical formulations containing flavonoid mixtures (often derived from plants like Glycyrrhiza glabra or Ruscus aculeatus) have shown some efficacy in reducing symptoms such as erythema, edema, and pruritus in patients with various types of dermatitis. Reviews and meta-analyses highlight the need for more robust clinical trials, but the available evidence supports a moderate level of efficacy, particularly for topical use.

Overall, while traditional use exists for some flavonoid-rich herbal preparations, the justification for their use in dermatitis is primarily supported by mechanistic and clinical scientific studies. However, the current evidence is not strong enough to replace established therapies, and further research is necessary to confirm optimal formulations, dosing, and long-term safety.