German Chamomile (Matricaria recutita) has been traditionally used for various inflammatory skin conditions, including dermatitis. In recent decades, scientific studies have explored its efficacy for this indication. The active constituents, such as chamazulene, α-bisabolol, and apigenin, have demonstrated anti-inflammatory, antioxidant, and mild antimicrobial properties in laboratory and animal studies. Clinical trials in humans, while somewhat limited and generally small in scale, have provided moderate evidence for its effectiveness.

Several randomized controlled trials have assessed chamomile creams or ointments for atopic or contact dermatitis. For example, a 1987 German study found that a chamomile extract cream was as effective as low-potency hydrocortisone in reducing symptoms of eczema. Other studies have shown chamomile preparations outperforming placebo for reducing inflammation, itching, and redness associated with dermatitis. The mechanism is thought to be related to the inhibition of pro-inflammatory cytokines and modulation of the skin barrier function.

However, the overall quality of evidence is moderate: studies are often small, and formulations of chamomile extracts can vary. Adverse effects are rare but possible, including allergic reactions in sensitive individuals. Overall, the use of German Chamomile for dermatitis is supported by both traditional use and a moderate level of scientific evidence, warranting a cautious but reasonable recommendation, especially as an adjunct to conventional therapies.