Evidence supporting the use of: Gotu kola
For the health condition: Dermatitis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Gotu kola (Centella asiatica) has a longstanding history of use in traditional medicine systems, such as Ayurveda and Traditional Chinese Medicine, for treating various skin conditions including dermatitis. Modern scientific research has begun to validate some of these traditional uses, particularly due to the plant’s bioactive compounds, such as asiaticoside, madecassoside, and asiatic acid. These triterpenoids have demonstrated anti-inflammatory, antioxidant, and wound-healing properties in both in vitro and in vivo studies.

Several studies have shown that topical formulations containing gotu kola extracts can improve symptoms associated with dermatitis, such as inflammation, itching, and skin barrier dysfunction. For example, a 2017 review in the International Journal of Molecular Sciences highlighted Centella asiatica’s potential to modulate inflammatory cytokines and promote collagen synthesis, both of which are relevant to dermatitis management. Clinical trials are limited but promising: small-scale studies show improvement in symptoms of atopic dermatitis and eczema when using creams or ointments with gotu kola extracts, often in combination with other herbal ingredients.

While the evidence is not yet robust enough for universal clinical recommendation (hence a moderate evidence score), the available data, combined with a favorable safety profile in topical use, support the use of gotu kola as a complementary approach for managing dermatitis symptoms. Larger, well-designed human trials are needed for more definitive conclusions.

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Aloe vera
alpha-pinene
beeswax
beta caryophyllene
bisabolol
black currant
black walnut
burdock
Cannabis sativa oil
chamomile
coating
turmeric
forsythia
garlic bulb
ginger
gotu kola
green tea
hemp oil
hyaluronic acid
Lactoperoxidase
lauric acid
Niacinamide (vitamin B3)
oregon grape
phenolic compounds
plantain
pomegranate
purified silver
quercetin
resveratrol
riboflavin (vitamin B2)
rosemary
schizonepeta
scrophularia root
specialized pro-resolving mediators (SPMs)
Sphaeranthus indicus
vitamin A
vitamin D
vitamin E
Zinc
chickweed
xanthium (cockleburs)
Mugwort
Neem tree
commiphora
siler root
oriental arborvitae
birch
polyphenols
fulvic acid
eucalyptus
Menthol oil
melaleuca alternifolia
geranium
avens
alpha-terpineol
azelaic acid
Ardisia
anamu
Allantoin
Asteraceae
argan nut oil
bee propolis
babchi
Baphicacanthus cusia
Bidens pilosa
bishop\'s weed
Boswellic Acid
Butea monosperma
Barleria
bisabolene
bee products
Bombax
Bassia scoparia
coconut
Centella triterpenes
caryophyllene
Calendula
chlorophyllin
coconut oil
colloid
carvacrol
Curcuminoid
Chinese raisintree
curcumen
Centella asiatica
Centipeda
Curcuma
cannabidiol
Carthamus
copaiba oil
cannabigerol
chrysophanics
Dianthus
Epidermal Growth Factor
Eclipta
emu oil
Euphorbia
ethyl linoleate
flavonoids
fang-feng
fatty acids
Ficus simplicissima
fibroblast growth factor
gallic acid
Gnaphalium
glyceryl monolaurate
Growth factors
Glechoma hederacea
gallotannin
Glycyrrhetinic acid
heal-all
Hydrocolloid
henna
Himalaya berry
hemp
iridoid glycosides
Indian fagonia
jojoba oil
Kokilaksha
Litsea
lichen
Laggera pterodonta
linseed oil
Lantana camara
Leptospermum scoparium
Labdanum
mallow
Melia
Malva sylvestris
mangostin
Mahonia
Milkweed
Marine colloids
marigold
Marking Nut Tree
Macaranga indica
Nigella seed
Oxystelma
Propolis
Phyllanthus
Pentacyclic triterpenoids
Paris polyphylla
Pansit-pansitan
Panthenol
Patrinia
Palmitoylethanolamide (PEA)
Peptides
rue
rosmarinic acid
reed herb
Squalene
Sichuan Lovage
Sicklepod
Sophora
Sesbania
Solanaceae
Shark Liver Oil
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Sweet Annie
Salvia
Sensitive Plant
Southern Tsangshu
Silk protein
Sandalwood
Sulfur
Storax
Terpenoids
Thymoquinone
Terpinen-4-ol
Thymus
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Wrightia tinctoria
Witch Hazel
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