Evidence supporting the use of: Iridoid glycosides
For the health condition: Dermatitis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Iridoid glycosides are a class of phytochemicals found in various medicinal plants such as Plantago lanceolata (plantain), Harpagophytum procumbens (devil’s claw), and Scrophularia species. These compounds have drawn attention for their anti-inflammatory and immunomodulatory properties. Several in vitro and animal studies suggest that iridoid glycosides can inhibit the release of pro-inflammatory cytokines and reduce oxidative stress, mechanisms implicated in the pathogenesis of dermatitis. For example, aucubin and catalpol, two well-studied iridoid glycosides, have demonstrated the ability to reduce skin inflammation in animal models of contact dermatitis and atopic dermatitis by downregulating inflammatory mediators such as TNF-α and IL-6.

Despite promising preclinical data, robust clinical evidence in humans is limited. A few small-scale clinical studies and case reports exist for topical preparations containing plant extracts rich in iridoid glycosides, showing some benefit in mild-to-moderate eczema or dermatitis. However, these studies often lack rigorous controls or use whole plant extracts rather than isolated iridoid glycosides, making it difficult to attribute benefits specifically to these compounds. As such, while there is a scientific rationale and some early evidence supporting the use of iridoid glycosides for dermatitis, the overall quality and quantity of human evidence is modest, justifying a low-to-moderate evidence rating.

More about Iridoid glycosides
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Other ingredients used for Dermatitis

Aloe vera
alpha-pinene
beeswax
beta caryophyllene
bisabolol
black currant
black walnut
burdock
cannabis sativa oil
chamomile
coating
turmeric
forsythia
garlic bulb
ginger
gotu kola
green tea
hemp oil
hyaluronic acid
lactoperoxidase
lauric acid
niacinamide (Vitamin B3)
oregon grape
phenolic compounds
plantain
pomegranate
purified silver
quercetin
resveratrol
riboflavin (vitamin B2)
rosemary
schizonepeta
scrophularia root
specialized pro-resolving mediators (SPMs)
sphaeranthus indicus
vitamin A
vitamin D
vitamin E
zinc
chickweed
xanthium (cockleburs)
mugwort
neem tree
commiphora
siler root
oriental arborvitae
birch
polyphenols
fulvic acid
eucalyptus
menthol oil
melaleuca alternifolia
geranium
Avens
Alpha-terpineol
Azelaic acid
Ardisia
Anamu
Allantoin
Asteracea
Argan nut oil
Bee Propolis
Babchi
Baphicacanthus cusia
Bidens pilosa
Bishop's Weed
Boswellic Acid
Butea monosperma
Barleria
Bisabolene
Bee products
Bombax
Bassia scoparia
Coconut
Centella triterpenes
Caryophyllene
Calendula
Chlorophyllin
coconut oil
Colloid
Carvacrol
Curcuminoid
Chinese Raisintree
Curcumen
Centella asiatica
Centipeda
Curcuma
Cannabidiol
Carthamus
Copaiba Oil
Cannabigerol
Chrysophanics
Dianthus
Epidermal Growth Factor
Eclipta
Emu Oil
Euphorbia
Ethyl Linoleate
Flavonoids
Fang-Feng
Fatty acids
Ficus simplicissima
fibroblast growth factor
Gallic Acid
Gnaphalium
Glyceryl monolaurate
Growth factors
Glechoma hederacea
Gallotannin
Glycyrrhetinic Acid
Heal-All
Hydrocolloid
Henna
Himalaya Berry
Hemp
Iridoid glycosides
Indian Fagonia
Jojoba Oil
Kokilaksha
Litsea
Lichen
Laggera pterodonta
Linseed Oil
Lantana camara
Leptospermum scoparium
Labdanum
Mallow
Melia
Malva sylvestris
Mangostin
Mahonia
Milkweed
Marine colloids
Marigold
Marking Nut Tree
Macaranga indica
Nigella Seed
Oxystelma
Propolis
Phyllanthus
Pentacyclic triterpenoids
Paris polyphylla
Pansit-pansitan
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Patrinia
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Peptides
Rue
Rosmarinic Acid
Reed Herb
Squalene
Sichuan Lovage
Sicklepod
Sophora
Sesbania
Solanaceae
Shark Liver Oil
Self-Heal
Sweet Annie
Salvia
Sensitive Plant
Southern Tsangshu
Silk protein
Sandalwood
Sulfur
Storax
Terpenoids
Thymoquinone
Terpinen-4-ol
Thymus
Thymol
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Violet
Wrightia tinctoria
Witch Hazel
Zingiberene

Products containing Iridoid glycosides

We currently have no products on Vitabase that contain this ingredient.