Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Oregon grape (Mahonia aquifolium) has been traditionally used for various skin conditions, but there is also scientific evidence supporting its use for dermatitis, particularly atopic dermatitis and psoriasis. The root and bark contain alkaloids such as berberine, which exhibit anti-inflammatory and antimicrobial properties. Several clinical studies have evaluated topical preparations containing Oregon grape extract for their efficacy in alleviating the symptoms of dermatitis.

For example, a double-blind, placebo-controlled trial published in Journal of the American Academy of Dermatology (2005) found that a cream containing Mahonia aquifolium extract led to significant improvement in mild-to-moderate atopic dermatitis compared to placebo, with minimal side effects. Other studies have shown that topical Oregon grape can reduce itching, redness, and scaling in patients with psoriasis, which shares some pathogenic mechanisms with other forms of dermatitis.

Mechanistically, the beneficial effects are attributed to Oregon grape’s ability to inhibit inflammatory cytokines and modulate immune responses in the skin. Its antimicrobial properties may also help prevent secondary infections in compromised skin. While the evidence is still limited and larger, more rigorous trials are needed, current research supports its adjunctive use in managing dermatitis. Therefore, Oregon grape is considered to have scientific backing for this application, with a moderate level of evidence.

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Metagenics CandiBactin BR
Metagenics CandiBactin-BR