Pansit-pansitan (Peperomia pellucida) is traditionally used in various cultures, especially in the Philippines and other parts of Southeast Asia, for treating skin ailments, including dermatitis. Historically, fresh leaves have been applied topically to soothe skin inflammation, itching, and rashes. The plant's popularity in folk medicine is largely attributed to its perceived anti-inflammatory and antimicrobial properties. However, scientific validation for its effectiveness specifically against dermatitis is limited.

A few laboratory studies have demonstrated that extracts of Peperomia pellucida contain bioactive compounds, such as flavonoids and alkaloids, which may exert anti-inflammatory effects. These findings suggest a possible mechanism for its traditional use in treating skin inflammation. However, robust clinical trials or controlled studies specifically addressing its use for dermatitis in humans are lacking. Most available evidence is in vitro or based on animal models focusing on general anti-inflammatory or wound-healing effects rather than direct evaluation in dermatitis patients.

In summary, the use of pansit-pansitan to support or treat dermatitis is primarily grounded in traditional practices, with limited low-level scientific evidence supporting its anti-inflammatory potential. Until more rigorous clinical research is conducted, its use for dermatitis should be considered as complementary and based on traditional knowledge rather than well-established scientific proof.