Evidence supporting the use of: Peptides
For the health condition: Dermatitis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Peptides, particularly bioactive peptides and synthetic peptides like palmitoyl pentapeptide, are increasingly used in dermatology, including as adjuncts in the management of dermatitis. Scientific evidence suggests that certain peptides possess anti-inflammatory, immunomodulatory, and barrier-restoring properties that can be beneficial in skin conditions characterized by inflammation and impaired barrier function, such as atopic dermatitis. For instance, antimicrobial peptides (AMPs), naturally present in the skin, play a critical role in innate immunity and help regulate microbial balance and inflammation. Some studies have explored topical formulations containing peptides that mimic or enhance these natural peptides, aiming to reduce inflammation, improve skin hydration, and support barrier repair.

However, while there is growing preclinical and limited clinical evidence indicating potential benefits, robust, large-scale, randomized controlled trials in humans are still lacking. Most of the supportive data comes from in vitro studies, animal models, or small pilot human studies. Consequently, the overall evidence base remains moderate and does not yet fully substantiate the widespread use of peptides as a primary or standalone treatment for dermatitis. They are more commonly considered as supportive or adjunctive agents rather than first-line therapies. Thus, while the use of peptides for dermatitis is scientifically plausible and partially supported by emerging research, the strength of evidence is currently rated as moderate (2/5).

More about Peptides
More about Dermatitis

Other ingredients used for Dermatitis

Aloe vera
alpha-pinene
beeswax
beta caryophyllene
bisabolol
black currant
black walnut
burdock
cannabis sativa oil
chamomile
coating
turmeric
forsythia
garlic bulb
ginger
gotu kola
green tea
hemp oil
hyaluronic acid
lactoperoxidase
lauric acid
niacinamide (Vitamin B3)
oregon grape
phenolic compounds
plantain
pomegranate
purified silver
quercetin
resveratrol
riboflavin (vitamin B2)
rosemary
schizonepeta
scrophularia root
specialized pro-resolving mediators (SPMs)
sphaeranthus indicus
vitamin A
vitamin D
vitamin E
zinc
chickweed
xanthium (cockleburs)
mugwort
neem tree
commiphora
siler root
oriental arborvitae
birch
polyphenols
fulvic acid
eucalyptus
menthol oil
melaleuca alternifolia
geranium
Avens
Alpha-terpineol
Azelaic acid
Ardisia
Anamu
Allantoin
Asteracea
Argan nut oil
Bee Propolis
Babchi
Baphicacanthus cusia
Bidens pilosa
Bishop's Weed
Boswellic Acid
Butea monosperma
Barleria
Bisabolene
Bee products
Bombax
Bassia scoparia
Coconut
Centella triterpenes
Caryophyllene
Calendula
Chlorophyllin
coconut oil
Colloid
Carvacrol
Curcuminoid
Chinese Raisintree
Curcumen
Centella asiatica
Centipeda
Curcuma
Cannabidiol
Carthamus
Copaiba Oil
Cannabigerol
Chrysophanics
Dianthus
Epidermal Growth Factor
Eclipta
Emu Oil
Euphorbia
Ethyl Linoleate
Flavonoids
Fang-Feng
Fatty acids
Ficus simplicissima
fibroblast growth factor
Gallic Acid
Gnaphalium
Glyceryl monolaurate
Growth factors
Glechoma hederacea
Gallotannin
Glycyrrhetinic Acid
Heal-All
Hydrocolloid
Henna
Himalaya Berry
Hemp
Iridoid glycosides
Indian Fagonia
Jojoba Oil
Kokilaksha
Litsea
Lichen
Laggera pterodonta
Linseed Oil
Lantana camara
Leptospermum scoparium
Labdanum
Mallow
Melia
Malva sylvestris
Mangostin
Mahonia
Milkweed
Marine colloids
Marigold
Marking Nut Tree
Macaranga indica
Nigella Seed
Oxystelma
Propolis
Phyllanthus
Pentacyclic triterpenoids
Paris polyphylla
Pansit-pansitan
Panthenol
Patrinia
Palmitoylethanolamide (PEA)
Peptides
Rue
Rosmarinic Acid
Reed Herb
Squalene
Sichuan Lovage
Sicklepod
Sophora
Sesbania
Solanaceae
Shark Liver Oil
Self-Heal
Sweet Annie
Salvia
Sensitive Plant
Southern Tsangshu
Silk protein
Sandalwood
Sulfur
Storax
Terpenoids
Thymoquinone
Terpinen-4-ol
Thymus
Thymol
Tea Tree Oil
Violet
Wrightia tinctoria
Witch Hazel
Zingiberene

Products containing Peptides

We currently have no products on Vitabase that contain this ingredient.