Silk protein, particularly sericin, has been explored for dermatological applications, including the management of dermatitis. Scientific studies suggest that silk protein has beneficial properties such as moisture retention, anti-inflammatory effects, and enhancement of skin barrier function. A handful of small-scale clinical trials and in vitro studies have shown that silk fabrics or silk-derived creams can reduce symptoms of atopic dermatitis, such as pruritus (itching), redness, and dryness, when compared to conventional cotton fabrics or placebo creams. The proposed mechanisms include sericin's ability to form a protective layer on the skin, reduce transepidermal water loss, and modulate inflammatory cytokine levels. However, the overall quality of available evidence is modest, with limitations such as small sample sizes, short follow-up periods, and variability in silk protein formulations used across studies. Despite these limitations, the existing evidence does provide some scientific support for the adjunctive use of silk protein in managing dermatitis, though further large-scale, high-quality clinical trials are needed to fully establish efficacy and optimal usage guidelines.