Evidence supporting the use of: Terpinen-4-ol
For the health condition: Dermatitis

Links: Go back one page, Tool main page, Ingredients list, Health conditions list, Body systems list

Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Terpinen-4-ol is a major active component of tea tree oil (Melaleuca alternifolia), which has been studied for its potential use in the management of dermatitis, particularly atopic dermatitis and contact dermatitis. The scientific rationale for its use lies in its well-documented antimicrobial and anti-inflammatory properties. Several in vitro studies have shown that terpinen-4-ol can inhibit the growth of Staphylococcus aureus, a bacterium often implicated in exacerbating atopic dermatitis. Additionally, terpinen-4-ol exhibits anti-inflammatory effects by suppressing the production of pro-inflammatory cytokines such as TNF-α and IL-1β in various cell models.

Clinical evidence, while limited, provides some support. Small randomized controlled trials and case series have reported improvement in dermatitis symptoms, like erythema and pruritus, with topical application of tea tree oil formulations, which contain terpinen-4-ol as a primary constituent. However, the studies often suffer from small sample sizes and methodological limitations. Importantly, tea tree oil can cause allergic reactions or irritant dermatitis in some individuals, so its use requires caution.

In summary, the use of terpinen-4-ol for dermatitis has a foundation in scientific research, primarily due to its antimicrobial and anti-inflammatory activity. However, while promising, the clinical evidence is not robust, and more rigorous, large-scale studies are needed to fully validate its efficacy and safety in dermatitis management.

More about Terpinen-4-ol
More about Dermatitis

Products containing Terpinen-4-ol

We currently have no products on Vitabase that contain this ingredient.