Evidence supporting the use of: Terpinen-4-ol
For the health condition: Dermatitis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Terpinen-4-ol is a major active component of tea tree oil (Melaleuca alternifolia), which has been studied for its potential use in the management of dermatitis, particularly atopic dermatitis and contact dermatitis. The scientific rationale for its use lies in its well-documented antimicrobial and anti-inflammatory properties. Several in vitro studies have shown that terpinen-4-ol can inhibit the growth of Staphylococcus aureus, a bacterium often implicated in exacerbating atopic dermatitis. Additionally, terpinen-4-ol exhibits anti-inflammatory effects by suppressing the production of pro-inflammatory cytokines such as TNF-α and IL-1β in various cell models.

Clinical evidence, while limited, provides some support. Small randomized controlled trials and case series have reported improvement in dermatitis symptoms, like erythema and pruritus, with topical application of tea tree oil formulations, which contain terpinen-4-ol as a primary constituent. However, the studies often suffer from small sample sizes and methodological limitations. Importantly, tea tree oil can cause allergic reactions or irritant dermatitis in some individuals, so its use requires caution.

In summary, the use of terpinen-4-ol for dermatitis has a foundation in scientific research, primarily due to its antimicrobial and anti-inflammatory activity. However, while promising, the clinical evidence is not robust, and more rigorous, large-scale studies are needed to fully validate its efficacy and safety in dermatitis management.

More about Terpinen-4-ol
More about Dermatitis

Other ingredients used for Dermatitis

Aloe vera
alpha-pinene
beeswax
beta caryophyllene
bisabolol
black currant
black walnut
burdock
Cannabis sativa oil
chamomile
coating
turmeric
forsythia
garlic bulb
ginger
gotu kola
green tea
hemp oil
hyaluronic acid
Lactoperoxidase
lauric acid
Niacinamide (vitamin B3)
oregon grape
phenolic compounds
plantain
pomegranate
purified silver
quercetin
resveratrol
riboflavin (vitamin B2)
rosemary
schizonepeta
scrophularia root
specialized pro-resolving mediators (SPMs)
Sphaeranthus indicus
vitamin A
vitamin D
vitamin E
Zinc
chickweed
xanthium (cockleburs)
Mugwort
Neem tree
commiphora
siler root
oriental arborvitae
birch
polyphenols
fulvic acid
eucalyptus
Menthol oil
melaleuca alternifolia
geranium
avens
alpha-terpineol
azelaic acid
Ardisia
anamu
Allantoin
Asteraceae
argan nut oil
bee propolis
babchi
Baphicacanthus cusia
Bidens pilosa
bishop\'s weed
Boswellic Acid
Butea monosperma
Barleria
bisabolene
bee products
Bombax
Bassia scoparia
coconut
Centella triterpenes
caryophyllene
Calendula
chlorophyllin
coconut oil
colloid
carvacrol
Curcuminoid
Chinese raisintree
curcumen
Centella asiatica
Centipeda
Curcuma
cannabidiol
Carthamus
copaiba oil
cannabigerol
chrysophanics
Dianthus
Epidermal Growth Factor
Eclipta
emu oil
Euphorbia
ethyl linoleate
flavonoids
fang-feng
fatty acids
Ficus simplicissima
fibroblast growth factor
gallic acid
Gnaphalium
glyceryl monolaurate
Growth factors
Glechoma hederacea
gallotannin
Glycyrrhetinic acid
heal-all
Hydrocolloid
henna
Himalaya berry
hemp
iridoid glycosides
Indian fagonia
jojoba oil
Kokilaksha
Litsea
lichen
Laggera pterodonta
linseed oil
Lantana camara
Leptospermum scoparium
Labdanum
mallow
Melia
Malva sylvestris
mangostin
Mahonia
Milkweed
Marine colloids
marigold
Marking Nut Tree
Macaranga indica
Nigella seed
Oxystelma
Propolis
Phyllanthus
Pentacyclic triterpenoids
Paris polyphylla
Pansit-pansitan
Panthenol
Patrinia
Palmitoylethanolamide (PEA)
Peptides
rue
rosmarinic acid
reed herb
Squalene
Sichuan Lovage
Sicklepod
Sophora
Sesbania
Solanaceae
Shark Liver Oil
Self-Heal
Sweet Annie
Salvia
Sensitive Plant
Southern Tsangshu
Silk protein
Sandalwood
Sulfur
Storax
Terpenoids
Thymoquinone
Terpinen-4-ol
Thymus
Thymol
Tea Tree Oil
Violet
Wrightia tinctoria
Witch Hazel
Zingiberene

Products containing Terpinen-4-ol

We currently have no products on Vitabase that contain this ingredient.