Evidence supporting the use of: Urea
For the health condition: Dermatitis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Urea is scientifically validated as a topical treatment to support and manage dermatitis, particularly in its role as a keratolytic and humectant. Urea’s primary mechanism is to improve skin hydration by increasing the water content of the stratum corneum, making it useful for conditions characterized by dry, rough, or scaly skin, such as atopic dermatitis and contact dermatitis. Clinical studies have shown that urea-containing creams (at concentrations ranging from 5% to 40%) can reduce scaling, pruritus, and dryness in various dermatoses. For example, a randomized controlled trial published in the Journal of Dermatological Treatment (2012) demonstrated that a 10% urea cream significantly improved skin hydration and reduced symptoms in patients with atopic dermatitis compared to placebo. Urea also helps to enhance the penetration of topical corticosteroids, potentially increasing their efficacy in treating inflamed skin. However, urea is not a direct anti-inflammatory or immunomodulatory agent, so its use is primarily as adjunctive therapy to restore and maintain the skin barrier. Adverse effects are generally mild and limited to stinging or irritation, especially on fissured or inflamed skin. The overall quality of evidence supporting its use is moderate (rated 3/5), with most studies indicating benefit for symptomatic relief and barrier repair, but fewer large-scale or long-term trials. Urea is widely included in guidelines as an emollient for dermatitis, reflecting its established and scientifically validated role.

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Products containing Urea

We currently have no products on Vitabase that contain this ingredient.