Evidence supporting the use of: Vitamin A (mixed)
For the health condition: Dermatitis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin A (often supplied as "mixed" retinoids or carotenoids) has a scientifically supported, although limited, role in dermatology, particularly regarding disorders of keratinization and epithelial integrity. Its use for dermatitis specifically is based on its essential function in maintaining healthy skin and supporting immune function. Severe vitamin A deficiency can manifest with skin problems, including xerosis (dry, rough skin) and follicular hyperkeratosis, which can resemble certain types of dermatitis, and supplementation in deficient individuals rapidly improves the skin. However, for common forms of dermatitis (such as atopic dermatitis, contact dermatitis, or seborrheic dermatitis) in individuals with normal vitamin A levels, evidence supporting therapeutic benefit from additional vitamin A supplementation is weak and not broadly validated in randomized clinical trials.

Topical retinoids—derivatives of vitamin A—are used in dermatology for conditions like acne and psoriasis, but their role in the direct management of eczematous dermatitis is limited due to potential irritation. Some historical and small-scale studies have explored oral or topical vitamin A in skin diseases, but these do not establish routine use in dermatitis. Therefore, while there is a scientific rationale for vitamin A in cases of deficiency, evidence does not strongly support its use in otherwise healthy individuals with dermatitis. Supplementation should be reserved for those with proven deficiency, and excess vitamin A can be toxic.

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