Evidence supporting the use of: Vitamin E (delta-tocopherol)
For the health condition: Dermatitis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin E, including delta-tocopherol, has been studied for its potential benefits in dermatological conditions due to its antioxidant and anti-inflammatory properties. There is some scientific evidence that topical and, less commonly, oral forms of Vitamin E may help reduce symptoms associated with dermatitis, particularly atopic dermatitis. Several small clinical studies and experimental models have demonstrated improvement in skin barrier function, reduced inflammation, and decreased oxidative stress following Vitamin E supplementation or topical application. However, most research has focused on alpha-tocopherol, the most biologically active form of Vitamin E, rather than delta-tocopherol specifically. The evidence for delta-tocopherol is less robust, and head-to-head studies are lacking. A 2015 randomized controlled trial found that oral Vitamin E supplementation improved clinical symptoms and reduced eczema severity scores in patients with atopic dermatitis. Other studies have shown topical Vitamin E can reduce itch and support healing in irritated skin. Despite these findings, larger and more rigorous clinical trials are needed to confirm efficacy, clarify optimal dosing, and determine the relevance of delta-tocopherol compared to other forms. Overall, while there is a scientific rationale and some supportive evidence, it is limited and not specific to delta-tocopherol. The current evidence base supports only a modest benefit, reflected in the evidence rating of 2 out of 5.

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