Evidence supporting the use of: Inositol
For the health condition: Diabetes

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Inositol—specifically myo-inositol and D-chiro-inositol—is used to support glucose metabolism and insulin sensitivity, especially in certain populations with metabolic disorders such as polycystic ovary syndrome (PCOS) and type 2 diabetes. The scientific basis for its use comes primarily from clinical studies investigating its effects on insulin resistance, glycemic control, and metabolic parameters.

Inositol acts as a second messenger in insulin signaling pathways. Several randomized controlled trials (RCTs) and meta-analyses have shown that myo-inositol supplementation can improve markers of insulin sensitivity, decrease fasting insulin levels, and lower blood glucose in women with PCOS, a group at high risk for developing diabetes. There is also some evidence—though less robust—that inositol may help improve glycemic control in people with type 2 diabetes.

However, most of the strong data are in women with PCOS, not the broader diabetic population. The evidence in type 2 diabetes is promising but not conclusive, with some small studies suggesting benefit, but larger and longer-term trials are needed. No major traditional medical systems have used inositol as a diabetes remedy, so its use is based on modern biochemical understanding and clinical research. Overall, inositol is considered safe and may be a useful adjunct for specific populations, but it is not a substitute for established diabetes treatments.

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