Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Resveratrol, a polyphenolic compound found in grapes, berries, and peanuts, has attracted scientific interest for its potential benefits in managing diabetes, particularly type 2 diabetes mellitus (T2DM). The primary rationale for its use is based on preclinical and limited clinical studies suggesting resveratrol may improve insulin sensitivity, reduce oxidative stress, and modulate glucose metabolism. Animal studies have consistently shown that resveratrol supplementation can lower blood glucose levels, enhance glucose uptake in muscle tissue, and improve pancreatic β-cell function. These effects are thought to be mediated through the activation of SIRT1 and AMPK pathways, both of which play roles in cellular energy regulation and insulin signaling. Human trials, however, are less conclusive. Small-scale clinical studies have reported modest improvements in fasting blood glucose, HbA1c, and insulin sensitivity, but the results are inconsistent and often limited by short duration, low participant numbers, and varying dosages of resveratrol. Meta-analyses indicate some potential benefit, but emphasize the need for larger, well-controlled studies to confirm efficacy and safety. While resveratrol is not a traditional remedy for diabetes, its use is justified by a growing body of scientific evidence, although the overall quality and quantity of this evidence remains moderate at best. Current guidelines do not recommend resveratrol as a standard treatment for diabetes, but ongoing research may clarify its role in the future.

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