Evidence supporting the use of: Vitamin D3
For the health condition: Diabetes

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin D3 (cholecalciferol) has garnered scientific interest in relation to diabetes, particularly type 2 diabetes mellitus (T2DM), due to its role in glucose metabolism and insulin sensitivity. Epidemiological studies have observed that individuals with low vitamin D levels are at increased risk of developing T2DM. Vitamin D receptors are present in pancreatic beta cells, which are responsible for insulin secretion, and in peripheral tissues involved in glucose metabolism. Laboratory and animal studies suggest vitamin D may enhance insulin secretion and reduce inflammation, factors that contribute to the development and progression of diabetes.

However, clinical trial evidence in humans is mixed. Some randomized controlled trials (RCTs) have shown modest improvements in insulin sensitivity or glycemic control with vitamin D supplementation, particularly in individuals who are vitamin D deficient at baseline. Other trials, however, have found no significant benefit. The largest meta-analyses indicate that while vitamin D supplementation may modestly improve fasting glucose and insulin resistance in prediabetic or deficient populations, the effect size is small and not universally observed.

Current diabetes guidelines do not recommend vitamin D supplementation specifically for diabetes prevention or management unless there is a documented deficiency. The scientific rationale is plausible and there is some supportive evidence, but it is not strong or consistent enough to warrant widespread use solely for diabetes control. Therefore, the evidence rate is 2/5, meaning there is preliminary scientific support but not definitive clinical validation.

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Douglas Laboratories Ultra Preventive ®-EZ Swallow
Douglas Laboratories ULTRA PREVENTIVE® III W/COPPER
Douglas Laboratories Ultra Preventive ® Kids Grape Flavor
Douglas Laboratories Ultra Preventive ® Kids Orange Flavor
Douglas Laboratories Ultra Preventive One Daily
Douglas Laboratories Ultra Preventive® X
Metagenics Ultra Prostagen Concentrated
Douglas Laboratories Ultra Protein Green
Pure Encapsulations Ultra Pure Pack
Metagenics UltraClear Detox Powder
Metagenics UltraClear Plus® Detox Powder
Metagenics UltraClear Plus Detox Powder Berry
Metagenics UltraClear Plus Detox Powder Pineapple/Banana
Metagenics UltraClear Plus pH Detox Powder Pineapple/Banana
Metagenics UltraClear Plus pH Detox Powder Vanilla
Metagenics UltraClear RENEW Detox Powder Berry
Metagenics UltraClear RENEW Detox Powder Chai
Metagenics UltraClear RENEW Detox Powder Vanilla
Pure Encapsulations UltraDetox 10-Day Pure Pack
Metagenics UltraGI Replenish® Chocolate
Metagenics UltraGI Replenish Chocolate
Metagenics UltraGI Replenish Vanilla
Metagenics UltraGI Replenish Vanilla
Metagenics UltraInflamX Plus 360°® Chocolate/Orange
Metagenics UltraInflamX Plus 360° Mango
Metagenics UltraInflamX Plus 360° Mango
Metagenics UltraInflamX Plus 360° Orange
Metagenics UltraInflamX Plus 360° Original Spice
Metagenics UltraInflamX Plus 360° Pineapple/Banana
Metagenics UltraInflamX Plus 360° Pineapple/Banana
Metagenics UltraMeal Advanced Protein® Dutch Chocolate
Metagenics UltraMeal Advanced Protein French Vanilla
Metagenics UltraMeal Advanced Protein Plain
Metagenics UltraMeal Cardio 360°® Pea/Rice Chocolate
Metagenics UltraMeal Cardio 360° Pea/Rice Vanilla
Metagenics UltraMeal® Daily Support Dutch Chocolate
Metagenics UltraMeal Daily Support Mixed Berry
Metagenics UltraMeal Rice Vanilla
Pure Encapsulations UltraNutrient®
Pure Encapsulations UltraNutrient®
Pure Encapsulations UltraNutrient®
Pure Encapsulations VisionPro Nutrients
Thorne Vitamin D-1,000
Douglas Laboratories Vitamin D 1,000 I.U.
Thorne Vitamin D-10,000
Vitabase Vitamin D-3
Douglas Laboratories Vitamin D 5,000 I.U.
Douglas Laboratories Vitamin D 5,000 I.U.
Thorne Vitamin D-5000 NSF
Thorne Vitamin D + K2
Thorne Vitamin D Liquid
Designs For Health Vitamin D Supreme
Designs For Health Vitamin D Supreme
Designs For Health Vitamin D Supreme
Designs For Health Vitamin D Synergy
Pure Encapsulations Vitamin D3
Pure Encapsulations Vitamin D3 10 mcg 400 IU
Metagenics Vitamin D3 1000™
Vitabase Vitamin D3 1000 IU
Metagenics Vitamin D3 10,000 + K
Pure Encapsulations Vitamin D3 125 mcg 5,000 IU
Pure Encapsulations Vitamin D3 125 mcg 5,000 IU
Pure Encapsulations Vitamin D3 125 mcg 5,000 IU
Metagenics Vitamin D3 2000 Complex
Integrative Therapeutics Vitamin D3 2000 iu
Pure Encapsulations Vitamin D3 25 mcg 1,000 IU
Pure Encapsulations Vitamin D3 25 mcg 1,000 IU
Pure Encapsulations Vitamin D3 25 mcg 1,000 IU
Pure Encapsulations Vitamin D3 250 mcg 10,000 IU
Pure Encapsulations Vitamin D3 250 mcg 10,000 IU
Metagenics Vitamin D3 5000
Metagenics Vitamin D3 5000 + K
Metagenics Vitamin D3 Liquid
Pure Encapsulations Vitamin D3 Vegan
Pure Encapsulations Vitamin D3 Vegan
Pure Encapsulations Vitamin D3 VESIsorb®
Integrative Therapeutics Vitamin K2+D3
Metagenics Wellness Essentials Active Daily Packs
Metagenics Wellness Essentials Brain Health Daily Packs
Metagenics Wellness Essentials® Daily Packs
Metagenics Wellness Essentials Healthy Balance Daily Packs
Metagenics Wellness Essentials Men's Vitality Daily Packs
Metagenics Wellness Essentials Women's Daily Packs
Metagenics Wellness Essentials Women's Prime Daily Packs
Thorne Women's Multi 50+
Pure Encapsulations Women's Nutrients
Designs For Health Women's Twice Daily Essential Packets