Evidence supporting the use of: Bioflavonoids (mixed)
For the health condition: Diabetic Retinopathy

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Bioflavonoids (also referred to as flavonoids) are a diverse group of plant compounds found in fruits, vegetables, and some supplements. Their use in supporting or treating diabetic retinopathy is primarily supported by scientific rationale, rather than traditional medicine. Bioflavonoids are known for their antioxidant and vasoprotective properties, which have led researchers to investigate their potential in diabetic retinopathy—a condition characterized by oxidative stress and microvascular damage in the retina due to diabetes. Several preclinical studies and a limited number of small clinical trials suggest that certain flavonoids, such as quercetin, rutin, and hesperidin, may help reduce capillary permeability and fragility, inhibit platelet aggregation, and exert antioxidative effects in retinal tissues. These mechanisms are relevant to the pathogenesis of diabetic retinopathy. Some studies have reported that supplementation with bioflavonoids can slow the progression of early-stage diabetic retinopathy and reduce retinal hemorrhages. However, the clinical evidence is limited and mixed. Most studies are small, of short duration, or use mixed flavonoid preparations, making it difficult to generalize findings or recommend specific dosages. There is no consensus in major diabetes or ophthalmology guidelines supporting the routine use of bioflavonoids for diabetic retinopathy. Overall, while there is a plausible scientific basis and some preliminary supportive evidence, robust, large-scale clinical trials are lacking.

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