Evidence supporting the use of: Panthenol
For the health condition: Diaper Rash

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Panthenol, also known as provitamin B5, is included in some diaper rash products due to its well-documented skin-soothing and barrier-supporting properties. Scientifically, panthenol is known to improve stratum corneum hydration, reduce transepidermal water loss, and support the skin’s barrier function. Several in vitro and in vivo studies have demonstrated panthenol’s efficacy in supporting wound healing, reducing inflammation, and enhancing recovery of irritated skin. Its moisturizing effect is particularly relevant in diaper rash, where the skin barrier is compromised by moisture, friction, and exposure to irritants.

Clinical studies in infants specifically for diaper dermatitis are limited but do exist. For example, some randomized controlled trials have shown that ointments containing panthenol (often in combination with other ingredients like dexpanthenol or zinc oxide) can help reduce the severity of diaper rash and accelerate healing. However, the evidence is not as robust as for some other established agents (such as zinc oxide alone), and many studies feature combination products, making it difficult to attribute efficacy solely to panthenol. Nonetheless, its inclusion is supported by a moderate body of scientific evidence for its skin barrier-supporting and soothing effects, justifying its use in this context.

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Products containing Panthenol

We currently have no products on Vitabase that contain this ingredient.