Prepared Aconite Tuber (commonly processed as "Fuzi" in traditional Chinese medicine) has been historically used in some traditional medicine systems, particularly in East Asia, for various ailments, including conditions associated with fever, inflammation, and severe throat infections. In the context of diphtheria—a serious bacterial infection characterized by sore throat, fever, and the formation of a pseudomembrane in the throat—references in classical Chinese medical texts have mentioned the use of Fuzi as part of multi-herb formulas intended to "expel toxins" or address "throat blockages." However, the rationale for its use is grounded in traditional concepts such as "warming the yang" and dispelling "cold," rather than directly targeting the bacterial cause of diphtheria as understood by modern medicine.

There is no scientific or clinical evidence to support the efficacy or safety of Prepared Aconite Tuber for treating diphtheria. In fact, Aconite is known to be highly toxic if not properly processed, and its use is strictly regulated in many countries. Modern treatment of diphtheria relies on antitoxin administration and antibiotics. Historical use in traditional medicine does not equate to evidence of efficacy, and the risk of serious toxicity makes the use of Aconite for diphtheria inadvisable according to current medical standards.