Evidence supporting the use of: Sodium Butyrate
For the health condition: Diverticulitis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Sodium butyrate, a salt form of butyric acid, is a short-chain fatty acid (SCFA) produced naturally in the colon through the fermentation of dietary fiber by gut bacteria. Its potential use in diverticulitis is based on its roles in supporting colonic mucosal health, reducing inflammation, and modulating the gut microbiota. Several small clinical studies and animal experiments suggest that butyrate supplementation can improve symptoms in patients with diverticular disease, particularly in cases of symptomatic uncomplicated diverticular disease (SUDD), a condition related to but distinct from acute diverticulitis.

For example, a randomized controlled trial (Krokowicz et al., 2014) showed that oral sodium butyrate reduced abdominal pain and improved quality of life in patients with SUDD. The proposed mechanisms include anti-inflammatory effects, promotion of mucosal healing, and enhancement of colonic barrier function. However, evidence specifically addressing the use of sodium butyrate in treating active diverticulitis is limited. Most studies focus on preventing recurrence or managing chronic symptoms rather than acute infection or inflammation.

Systematic reviews (e.g., Tursi et al., 2020) conclude that while butyrate shows promise as an adjunct therapy in diverticular disease, high-quality data for its efficacy in acute diverticulitis are lacking. Therefore, scientific support exists but is still preliminary, and further research is needed to define its role in acute diverticulitis management.

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