Evidence supporting the use of: Ligustilide
For the health condition: Dizziness

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Ligustilide is a phthalide compound primarily found in plants such as Angelica sinensis (Dong Quai) and Ligusticum chuanxiong (Szechuan lovage), which have a long history of use in traditional Chinese medicine (TCM). In TCM, these herbs are commonly prescribed to "invigorate blood circulation" and "dispel wind," concepts that are typically associated with alleviating symptoms such as dizziness, headaches, and menstrual irregularities. The use of ligustilide-containing herbs for dizziness is largely based on these traditional principles rather than robust scientific evidence.

While there are some preclinical studies suggesting that ligustilide possesses neuroprotective, vasodilatory, and anti-inflammatory properties, direct clinical evidence supporting its use specifically for dizziness in humans is lacking. Most available studies focus on the compound’s effects on cerebral blood flow, oxidative stress, and neuroinflammation in animal models or cell cultures, rather than on dizziness as a symptom or medical condition. Consequently, the rationale for using ligustilide to support or treat dizziness is rooted in traditional medical practice rather than validated by modern clinical research. The evidence rating reflects the limited scientific substantiation, with most support derived from historical and anecdotal usage.

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