Evidence supporting the use of: Ligustrazin
For the health condition: Dizziness

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Ligustrazin, also known as tetramethylpyrazine, is an active compound extracted from the traditional Chinese medicinal herb Ligusticum chuanxiong (Szechuan lovage). Its use for dizziness is primarily rooted in traditional Chinese medicine (TCM), where the herb is said to “invigorate blood circulation” and “dispel wind,” which are thought in TCM theory to address causes of dizziness such as “blood stasis” or “blockage of meridians.” Ligustrazin-containing preparations are commonly prescribed in China for symptoms like dizziness, headache, and vertigo, particularly when associated with cardiovascular or cerebrovascular conditions.

Scientific studies on ligustrazin for dizziness are limited and generally of low quality. Some preclinical research suggests ligustrazin may have vasodilatory effects, improve microcirculation, and protect against cerebral ischemia, which could theoretically reduce dizziness in cases related to poor blood flow. However, robust clinical trials specifically evaluating ligustrazin for dizziness are lacking, and most available evidence comes from small, poorly controlled studies or anecdotal reports. As such, while its use is widespread in TCM, the scientific validation supporting ligustrazin’s effectiveness for dizziness remains weak.

In summary, ligustrazin’s use for dizziness is mainly supported by traditional practice rather than high-quality scientific evidence. The current state of research justifies only a low-to-moderate rating (2/5) for evidence quality in this indication.

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