Active amines, such as phenylethylamine (PEA), tyramine, and tryptamine, are organic compounds that play various roles in neuromodulation and neurotransmission. Their relevance in supporting the dopamine system is grounded in scientific evidence, particularly in neurochemistry. Several active amines act as direct precursors or modulators of dopamine synthesis and release. For example, tyramine is structurally similar to dopamine and can influence dopamine release by acting on trace amine-associated receptors (TAARs), which in turn modulate monoaminergic systems, including dopaminergic pathways. Additionally, phenylethylamine can increase synaptic dopamine levels by promoting its release or inhibiting its reuptake, though its effect is relatively short-lived due to rapid metabolism by monoamine oxidase (MAO).

Clinical and preclinical studies have shown that these amines can transiently elevate mood and have stimulating effects, likely through their impact on dopamine and related neurotransmitters. However, most evidence derives from animal studies, acute dosing experiments, or in vitro systems, with limited long-term human data. Some dietary supplements use active amines or their precursors with the aim of enhancing mood, motivation, or energy via dopaminergic mechanisms. In summary, there is a scientific rationale and moderate evidence supporting the influence of active amines on the dopamine system, but more robust, long-term clinical trials are needed to establish efficacy and safety for ongoing human use.