Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Kanna (Sceletium tortuosum) is a succulent plant native to South Africa that has been used traditionally for mood enhancement and stress relief. Modern scientific interest has focused on its potential effects on neurotransmitter systems, including the dopamine system. Kanna contains alkaloids such as mesembrine, mesembrenone, and mesembrenol, which have been shown in vitro to act as selective serotonin reuptake inhibitors (SSRIs) and phosphodiesterase-4 (PDE4) inhibitors. Some preclinical studies suggest that kanna's alkaloids may also influence dopamine levels by inhibiting dopamine reuptake or modulating monoamine activity, potentially contributing to mood elevation and cognitive effects. However, robust clinical evidence in humans directly linking kanna supplementation to significant changes in the dopamine system is limited. Most human studies focus on kanna’s effects on anxiety, stress, and mood, rather than direct dopamine-related endpoints. While there is a plausible biochemical basis for kanna influencing dopamine pathways, the evidence remains preliminary. Therefore, while the use of kanna to support the dopamine body system is justified with some scientific rationale, the current evidence base is modest and primarily preclinical, warranting a rating of 2 out of 5.

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